Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil
Rev. Soc. Bras. Med. Trop
; 52: e20180376, 2019. tab, graf
Article
in En
| LILACS
| ID: biblio-1041562
Responsible library:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil.METHODS:
Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms.RESULTS:
Cryptococcus neoformans was detected as the predominant etiological agent (100%) in HIV-positive patients. No genetic polymorphic changes were found.CONCLUSIONS:
No correlation was observed between the analyzed TNFα polymorphisms and cryptococcal meningitis.Key words
Full text:
1
Index:
LILACS
Main subject:
Tumor Necrosis Factor-alpha
/
Meningitis, Cryptococcal
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
MEDICINA TROPICAL
Year:
2019
Type:
Article