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Evaluation of paediatric patients with protein losing enteropathy a single centre experience / Evaluación de los pacientes pediátricos con enteropatía perdedora de proteínas experiencia sola en un centro
Urganci, N; Gulec, SG; Kalyoncu, D; Karaman, S.
  • Urganci, N; Department of Paediatric Gastroenterology. TR
  • Gulec, SG; Sisli Etfal Training and Research Hospital. Department of Paediatrics. Istanbul. TR
  • Kalyoncu, D; Sisli Etfal Training and Research Hospital. Department of Paediatrics. Istanbul. TR
  • Karaman, S; Sisli Etfal Training and Research Hospital. Department of Paediatrics. Istanbul. TR
West Indian med. j ; 62(3): 181-185, Mar. 2013. tab
Article in English | LILACS | ID: biblio-1045623
ABSTRACT

OBJECTIVE:

The aim of the study is to evaluate paediatric patients with protein losing enteropathy (PLE).

METHODS:

Fourteen cases diagnosed as PLE were evaluated in terms of aetiologies, diagnostic methods, laboratory findings, treatment procedures and longterm prognosis.

RESULTS:

Four of the cases had coeliac disease, three intestinal lymphangiectasia, three giardia infection, one H pylori infection and three cytomegalovirus (CMV) infection. Histopathological examinations of duodenum specimens revealed total villous atrophy in four cases, lymphatic dilatation in three cases, severe nodular appearance in four cases and no pathology in four cases. All of the cases except patients with intestinal lymphangiectasia were controlled by the appropriate treatment given for the underlying disease. The cases with CMV infection were treated with only supportive treatment and gancyclovir therapy was not needed.

CONCLUSION:

When proteinuria is not detected in wellappearing children admitted with oedema, PLE must be considered.
RESUMEN

OBJETIVO:

El objetivo del estudio es evaluar a pacientes con enteropatía perdedora de proteínas (EPP).

MÉTODOS:

Catorce casos diagnosticados con EPP fueron evaluados en términos de etiologías, métodos de diagnóstico, resultados de laboratorio, procedimientos de tratamiento, y prognósis a largo plazo.

RESULTADOS:

Cuatro de los casos tenían enfermedad celíaca, tres padecían de linfangiectasia intestinal, tres sufrían de infección por giardias, uno tenía infección por H pylori, y tres presentaba infección por citomegalovirus (CMV). Los exámenes histopatológicos de especímenes duodenales revelaron atrofia de las vellosidades intestinales en cuatro de los casos, dilatación linfática en tres casos, apariencia nodular severa en cuatro casos, y ausencia de patología en cuatro casos. Todos los casos - excepto los pacientes con linfangiectasia intestinal - fueron controlados mediante el tratamiento adecuado para la enfermedad subyacente. Los casos con infección por CMV fueron tratados con tratamiento de apoyo, y no se necesitó terapia con ganciclovir.

CONCLUSIÓN:

Cuando no se detecta proteinuria en niños con buena apariencia ingresados con edema, hay que considerar principalmente la posibilidad de EPP.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Protein-Losing Enteropathies Type of study: Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Pregnancy Language: English Journal: West Indian med. j Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Turkey Institution/Affiliation country: Department of Paediatric Gastroenterology/TR / Sisli Etfal Training and Research Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Protein-Losing Enteropathies Type of study: Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Pregnancy Language: English Journal: West Indian med. j Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Turkey Institution/Affiliation country: Department of Paediatric Gastroenterology/TR / Sisli Etfal Training and Research Hospital/TR