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Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin
Cardoso, Nathália Sigilló; Ribeiro, Victor Barbosa; Dutra, Sabrina Graziani Veloso; Ferriani, Rui Alberto; Gastaldi, Ada Clarice; Araújo, João Eduardo de; Souza, Hugo Celso Dutra de.
  • Cardoso, Nathália Sigilló; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor. Ribeirão Preto. BR
  • Ribeiro, Victor Barbosa; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Ginecologia e Obstetrícia. Ribeirão Preto. BR
  • Dutra, Sabrina Graziani Veloso; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor. Ribeirão Preto. BR
  • Ferriani, Rui Alberto; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Ginecologia e Obstetrícia. Ribeirão Preto. BR
  • Gastaldi, Ada Clarice; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor. Ribeirão Preto. BR
  • Araújo, João Eduardo de; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor. Ribeirão Preto. BR
  • Souza, Hugo Celso Dutra de; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor. Ribeirão Preto. BR
Arch. endocrinol. metab. (Online) ; 64(1): 4-10, Jan.-Feb. 2020. tab
Article in English | LILACS | ID: biblio-1088773
ABSTRACT
ABSTRACT Objective The aim of this study was to investigate polycystic ovary syndrome (PCOS) and to explore the relationship between body fat percentage and metabolic markers. Subjects and methods Sedentary women were assigned to PCOS (N = 60) and CONTROL (N = 60) groups. Each group was subdivided into three subgroups according to body fat percentage (22-27%, 27-32% and 32-37%). The protocol consisted of assessments of glucose, insulin, androgens, follicle stimulating hormone (FSH), luteinizing hormone (LH), 17-hydroxyprogesterone (17-OHP), leptin, adiponectin, tumor necrosis factor (TNF-α) and interleukin-6 (IL-6). Results The PCOS subgroups showed higher concentrations of androgens, LH and 17-OHP. Leptin showed direct relationship with increased body fat percentage, whereas adiponectin showed the inverse effect. However, both were unaffected by PCOS. TNF-α and IL-6 were higher in PCOS women and showed a direct relationship with increased body fat percentage. Glucose showed direct relationship with body fat percentage, whereas insulin presented higher values in PCOS women and direct relationship with increased body fat percentage. Conclusions Our findings indicate that PCOS and body fat percentage directly influence concentrations of insulin, TNF-α and IL-6, whereas leptin and adiponectin are influenced only by the increase in body fat percentage in these women. Arch Endocrinol Metab. 2020;64(1)4-10
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Biomarkers / Adipose Tissue / Metabolic Diseases Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Biomarkers / Adipose Tissue / Metabolic Diseases Type of study: Observational study / Risk factors Limits: Adolescent / Adult / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR