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Influenza A and B in a cohort of outpatient children and adolescent with influenza like-illness during two consecutive influenza seasons
Machado, Clarisse M; de Souza, Ana Carolina Mamana Fernandes; Romano, Camila Malta; dos Santos Freire, Wilton; Costa, Ângela Aparecida; Figueiredo, Walter Manso; Pannuti, Cláudio S; Luna, Expedito J A.
  • Machado, Clarisse M; Universidade de São Paulo. Instituto de Medicina Tropical. Laboratório de Virologia. São Paulo. BR
  • de Souza, Ana Carolina Mamana Fernandes; Universidade de São Paulo. Instituto de Medicina Tropical. Laboratório de Virologia. São Paulo. BR
  • Romano, Camila Malta; Universidade de São Paulo. Instituto de Medicina Tropical. Laboratório de Virologia. São Paulo. BR
  • dos Santos Freire, Wilton; Universidade de São Paulo. Instituto de Medicina Tropical. Laboratório de Virologia. São Paulo. BR
  • Costa, Ângela Aparecida; Serviço Especial de Saúde de Araraquara- SESA. Faculdade de Saúde Pública da USP. São Paulo. BR
  • Figueiredo, Walter Manso; Serviço Especial de Saúde de Araraquara- SESA. Faculdade de Saúde Pública da USP. São Paulo. BR
  • Pannuti, Cláudio S; Universidade de São Paulo. Instituto de Medicina Tropical. Laboratório de Virologia. São Paulo. BR
  • Luna, Expedito J A; Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Preventiva. São Paulo. BR
Braz. j. infect. dis ; 24(1): 73-80, Feb. 2020. tab, graf
Article in English | LILACS | ID: biblio-1089322
ABSTRACT
ABSTRACT Introduction Influenza is an important cause of morbimortality worldwide. Although people at the extremes of age have a greater risk of complications, influenza has been more frequently investigated in the elderly than in children, and inpatients than outpatients. Yearly vaccination with trivalent or quadrivalent vaccines is the main strategy to control influenza. Objectives Determine the clinical and molecular characteristics of influenza A and B infections in children and adolescents with influenza-like illness (ILI).

Methods:

A cohort of outpatient children and adolescents with ILI was followed for 20 months. Influenza was diagnosed with commercial multiplex PCR platforms.

Results:

179 patients had 277 episodes of ILI, being 79 episodes of influenza A and 20 episodes of influenza B. Influenza A and B cases were mild and had similar presentation. Phylogenetic tree of influenza B viruses showed that 91.6% belonged to the B/Yamagata lineage, which is not included in trivalent vaccines.

Conclusions:

Influenza A and B are often detected in children and adolescents with ILI episodes, with similar and mild presentation in outpatients. The mismatch between the circulating influenza viruses and the trivalent vaccine offered in Brazil may have contributed to the high frequency of influenza A and B in this population.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Influenza A virus / Influenza B virus / Outpatients / Influenza, Human Type of study: Observational study / Prognostic study / Risk factors Limits: Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Serviço Especial de Saúde de Araraquara- SESA/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Influenza A virus / Influenza B virus / Outpatients / Influenza, Human Type of study: Observational study / Prognostic study / Risk factors Limits: Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Serviço Especial de Saúde de Araraquara- SESA/BR / Universidade de São Paulo/BR