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C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning
Santana, Renato Figueiredo; Silva, Layla Alves Rodrigues da; Achar, Eduardo; Ballester, Gerson; Ribeiro Junior, Marcelo Augusto Fontenelle; Postgraduate Program in Health ScienceOrtiz, Sandra Regina Mota.
  • Santana, Renato Figueiredo; Universidade Cidade de São Paulo. Instituto de Assistência Médica ao Servidor Público Estadual. Postgraduate Program in Health Science. BR
  • Silva, Layla Alves Rodrigues da; IAMSPE. Sao Paulo. BR
  • Achar, Eduardo; UNICID. BR
  • Ballester, Gerson; UNICID. Sao Paulo. BR
  • Ribeiro Junior, Marcelo Augusto Fontenelle; Pontifícia Universidade Católica de São Paulo. Department of Surgery. Sorocaba. BR
  • Postgraduate Program in Health ScienceOrtiz, Sandra Regina Mota; USJT. IAMSPE. Postgraduate Program in Health ScienceOrtiz, Sandra Regina Mota. Sao Paulo. BR
Acta cir. bras ; 35(7): e202000705, 2020. tab, graf
Article in English | LILACS | ID: biblio-1130657
ABSTRACT
Abstract Purpose Studies have demonstrated that star fruit consumption by nephropathic patients triggers severe neurotoxic effects that can lead to convulsions or even death. Brain areas likely susceptible to star fruit poisoning have not been investigated. The objective of the present study was to map possible epileptogenic areas susceptible to star fruit intoxication in nephropathic rats. Methods The study analyzed 25 rats (5 groups). Rats in the experimental group underwent bilateral ureteral obstruction surgery and orogastric gavages with star fruit juice. An electroencephalogram was used to confirm convulsive seizures. Urea and creatinine levels were used to confirm the uremia model. Immunohistochemical analysis was used to map cells with c-Fos protein (c-Fos+ cells) to identify brain areas with increased neuronal activity. Control groups included non-nephropathic and nephropathic rats that did not receive star fruit. Results A statistically significant increase (p<0.01) in c-Fos+ cells was noted in nephropathic animals receiving star fruit juice compared to control groups, in brain areas commonly related to epileptogenic neural circuits including the hippocampus, amygdala, rhinal cortex, anterior cingulate area, piriform area, and medial dorsal thalamus. Conclusion These data corroborate the neurotoxic capacity of star fruit in nephropathic patients.
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Full text: Available Index: LILACS (Americas) Main subject: Proto-Oncogene Proteins c-fos / Fruit / Kidney Diseases Limits: Animals / Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: IAMSPE/BR / Pontifícia Universidade Católica de São Paulo/BR / UNICID/BR / USJT/BR / Universidade Cidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Proto-Oncogene Proteins c-fos / Fruit / Kidney Diseases Limits: Animals / Humans Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: IAMSPE/BR / Pontifícia Universidade Católica de São Paulo/BR / UNICID/BR / USJT/BR / Universidade Cidade de São Paulo/BR