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Insulina e polimorfismos do gene do receptor de insulina e a suscetibilidade à doença hepática gordurosa não alcoólica / Insulin and insulin receptor gene polymorphisms and susceptibility to nonalcoholic fatty liver disease
Nobakht, Hossein; Mahmoudi, Touraj; Sabzikarian, Mohammad; Tabaeian, Seidamir Pasha; Rezamand, Gholamreza; Asadi, Asadollah; Farahani, Hamid; Dabiri, Reza; Mansour-Ghanaei, Fariborz; Maleki, Iradj; Zali, Mohammad Reza.
  • Nobakht, Hossein; Semnan University of Medical Sciences. Internal Medicine Department. Semnan. IR
  • Mahmoudi, Touraj; Shahid Beheshti University of Medical Sciences. Research Institute for Gastroenterology and Liver Diseases. Gastroenterology and Liver Diseases Research Center. Tehran. IR
  • Sabzikarian, Mohammad; Iran University of Medical Sciences. Colorectal Research Center. Tehran. IR
  • Tabaeian, Seidamir Pasha; Iran University of Medical Sciences. Colorectal Research Center. Tehran. IR
  • Rezamand, Gholamreza; Iran University of Medical Sciences. Colorectal Research Center. Tehran. IR
  • Asadi, Asadollah; University of Mohaghegh Ardabili. Faculty of Science. Department of Biology. Ardabil. IR
  • Farahani, Hamid; Qom University of Medical Sciences. School of Medicine. Department of Physiology and Pharmacology. Qom. IR
  • Dabiri, Reza; Semnan University of Medical Sciences. Internal Medicine Department. Semnan. IR
  • Mansour-Ghanaei, Fariborz; Guilan University of Medical Sciences. Gastrointestinal and Liver Diseases Research Center (GLDRC). Division of Gastroenterology and Hepatology. Rasht. IR
  • Maleki, Iradj; Mazandaran University of Medical Sciences. Gut and Liver Research Center. Sari. IR
  • Zali, Mohammad Reza; Shahid Beheshti University of Medical Sciences. Research Institute for Gastroenterology and Liver Diseases. Gastroenterology and Liver Diseases Research Center. Tehran. IR
Arq. gastroenterol ; 57(2): 203-208, Apr.-June 2020. tab
Article in English | LILACS | ID: biblio-1131642
ABSTRACT
ABSTRACT

BACKGROUND:

Nonalcoholic fatty liver disease (NAFLD) is an increasing global health concern defined by excessive hepatic fat content in the absence of excessive alcohol consumption.

OBJECTIVE:

Given the pivotal role of insulin resistance in NAFLD, we hypothesized that insulin (INS) and insulin receptor (INSR) gene polymorphisms may be associated with NAFLD risk.

METHODS:

A total of 312 subjects, including 153 cases with biopsy-proven NAFLD and 159 controls were enrolled in this case-control study. Four polymorphisms in INS (rs3842752, rs689) and INSR (rs1052371, rs1799817) genes were genotyped using PCR-RFLP method.

RESULTS:

The cases with NAFLD were older and had higher BMI, systolic blood pressure, diastolic blood pressure, as well as higher serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma glutamyl transferase than the controls (P<0.001). The "TT" genotype of INSR rs1799817 compared with "CC" genotype occurred more frequently in the controls than the cases with NAFLD and the difference remained significant after adjustment for confounding factors (P=0.018; OR=0.10, 95%CI=0.02-0.76). However, no significant difference was found for INS rs3842752, INS rs689, and INSR rs1052371 gene polymorphisms between the cases with NAFLD and the controls either before or after adjustment for the confounders.

CONCLUSION:

These findings corroborate the hypothesis that genetic polymorphisms related to insulin resistance play a role in NAFLD susceptibility. Specifically, the INSR rs1799817 "TT" genotype had a protective effect for NAFLD. However, our results remain to be validated in other studies.
RESUMO
RESUMO

CONTEXTO:

A doença hepática gordurosa não alcoólica (NAFLD) é uma preocupação global crescente da saúde definida pelo excesso de teor de gordura hepática na ausência de consumo excessivo de álcool.

OBJETIVO:

Dado o papel crucial da resistência à insulina no NAFLD, criou-se a hipótese de que os polimorfismos genéticos da insulina (INS) e do receptor de insulina (INSR) podem estar associados ao risco de NAFLD.

MÉTODOS:

Um total de 312 indivíduos, incluindo 153 casos com NAFLD comprovado por biópsia e 159 controles foram inscritos neste estudo de caso-controle. Quatro polimorfismos em genes INS (rs3842752, rs689) e INSR (rs1052371, rs1799817) foram genotipados utilizando o método PCR-RFLP.

RESULTADOS:

Os casos com NAFLD foram mais idosos e apresentaram maior IMC, pressão arterial sistólica, pressão arterial diastólica, bem como níveis séricos mais elevados de aspartato aminotransferase, de alanina aminotransferase e de gama glutamil transpeptidase do que os controles (P<0,001). O genótipo "TT" de INSR rs1799817 em comparação com o genótipo "CC" ocorreu com mais frequência nos controles do que os casos com NAFLD e a diferença permaneceu significativa após ajuste para fatores de confusão (P=0,018; OR=0,10, IC95%=0,02-0,76). No entanto, não foi encontrada diferença significativa para INS rs3842752, INS rs689 e INSR rs1052371 polimorfismos genéticos entre os casos com NAFLD e os controles antes ou depois do ajuste para os fatores de confusão.

CONCLUSÃO:

Esses achados corroboram a hipótese de que os polimorfismos genéticos relacionados à resistência à insulina desempenham um papel na suscetibilidade do NAFLD. Especificamente, o genótipo INSR rs1799817 "TT" teve um efeito protetor para o NAFLD. No entanto, nossos resultados necessitam ser validados em outros estudos.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Receptor, Insulin / Genetic Predisposition to Disease / Non-alcoholic Fatty Liver Disease Type of study: Observational study / Risk factors Limits: Adult / Aged / Humans Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2020 Type: Article Affiliation country: Iran Institution/Affiliation country: Guilan University of Medical Sciences/IR / Iran University of Medical Sciences/IR / Mazandaran University of Medical Sciences/IR / Qom University of Medical Sciences/IR / Semnan University of Medical Sciences/IR / Shahid Beheshti University of Medical Sciences/IR / University of Mohaghegh Ardabili/IR

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Full text: Available Index: LILACS (Americas) Main subject: Receptor, Insulin / Genetic Predisposition to Disease / Non-alcoholic Fatty Liver Disease Type of study: Observational study / Risk factors Limits: Adult / Aged / Humans Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2020 Type: Article Affiliation country: Iran Institution/Affiliation country: Guilan University of Medical Sciences/IR / Iran University of Medical Sciences/IR / Mazandaran University of Medical Sciences/IR / Qom University of Medical Sciences/IR / Semnan University of Medical Sciences/IR / Shahid Beheshti University of Medical Sciences/IR / University of Mohaghegh Ardabili/IR