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REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells
Liu, Miao; Xu, Wanfu; Su, Mingmin; Fan, Pingsheng.
  • Liu, Miao; Shandong University. Cheeloo College of Medicine. Anhui Provincial Hospital. Jinan. CN
  • Xu, Wanfu; Guangzhou Medical University. Guangzhou Women and Childrens Medical Center. Department of Gastroenterology. Guangzhou. CN
  • Su, Mingmin; Cardiff University. School of Pharmacy and Pharmaceutical Sciences. Department of Cancer Biology and Therapeutics. Wales. GB
  • Fan, Pingsheng; Shandong University. Cheeloo College of Medicine. Anhui Provincial Hospital. Jinan. CN
Biol. Res ; 53: 41, 2020. graf
Article in English | LILACS | ID: biblio-1131885
ABSTRACT

BACKGROUND:

Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played a vital role in Epithelial-Mesenchymal Transition (EMT) in gastric cancer. However, the role of REC8 in gastric cancer angiogenesis remains to be identified.

RESULTS:

Inhibition of REC8 expression in gastric cancer cells contributed to tumor angiogenesis in the gastric cancer microenvironment. The clinical analysis demonstrated that the loss of REC8 in gastric cancer with enrichment of MVD. Depletion of REC8 expression in gastric cancer cells significantly increased tube formation of human umbilical vein endothelial cells (HUVECs), which is attributed to enhancement of vascular endothelial growth factor (VEGF) secretion caused by REC8 slicing. While addition of neutralizing antibody targeted VEGF into supernatant drastically reversed the effect of REC8 loss in gastric cancer cells on tube formation. Mechanistic analyses indicated that ablation of REC8 promotes nuclear factor-κB (NF-κB) p65 activity and its downstream gene VEGF expression, leading to tube formation.

CONCLUSIONS:

These results demonstrated a novel REC8 function that suppressed tumor angiogenesis and progression by attenuation of VEGF in gastric cancer microenvironment.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Stomach Neoplasms / NF-kappa B / Cell Cycle Proteins / Vascular Endothelial Growth Factor A / Neovascularization, Pathologic Type of study: Prognostic study Limits: Humans Language: English Journal: Biol. Res Journal subject: Biology Year: 2020 Type: Article Affiliation country: China / United kingdom Institution/Affiliation country: Cardiff University/GB / Guangzhou Medical University/CN / Shandong University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Stomach Neoplasms / NF-kappa B / Cell Cycle Proteins / Vascular Endothelial Growth Factor A / Neovascularization, Pathologic Type of study: Prognostic study Limits: Humans Language: English Journal: Biol. Res Journal subject: Biology Year: 2020 Type: Article Affiliation country: China / United kingdom Institution/Affiliation country: Cardiff University/GB / Guangzhou Medical University/CN / Shandong University/CN