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MiR-128 suppresses metastatic capacity by targeting metadherin in breast cancer cells
Cao, Danxia; Zhu, Han; Zhao, Qian; Huang, Jianming; Zhou, Cixiang; He, Jianrong; Liang, Yongjun.
  • Cao, Danxia; Shanghai Jiao Tong University School of Medicine. Shanghai Ruijin Hospital. Comprehensive Breast Health Center. Shanghai. CN
  • Zhu, Han; Fudan University Pudong Medical Center. Shanghai Pudong Hospital. Department of Pharmacy. Shanghai. CN
  • Zhao, Qian; Shanghai Jiao Tong University School of Medicine. Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education. Department of Pathophysiology. Shanghai. CN
  • Huang, Jianming; Fudan University Pudong Medical Center. Shanghai Pudong Hospital. Department of Orthopedics. Shanghai. CN
  • Zhou, Cixiang; Shanghai Jiao Tong University School of Medicine. Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education. Department of Pathophysiology. Shanghai. CN
  • He, Jianrong; Shanghai Jiao Tong University School of Medicine. Shanghai Ruijin Hospital. Comprehensive Breast Health Center. Shanghai. CN
  • Liang, Yongjun; Fudan University Pudong Medical Center. Shanghai Pudong Hospital. Center for Medical Research and Innovation. Shanghai. CN
Biol. Res ; 53: 43, 2020. tab, graf
Article in English | LILACS | ID: biblio-1131887
ABSTRACT

BACKGROUND:

Breast cancer, the most common cancer in women worldwide, causes the vast majority of cancer-related deaths. Undoubtedly, tumor metastasis and recurrence are responsible for more than 90 percent of these deaths. MicroRNAs are endogenous noncoding RNAs that have been integrated into almost all the physiological and pathological processes, including metastasis. In the present study, the role of miR-128 in breast cancer was investigated.

RESULTS:

Compared to the corresponding adjacent normal tissue, the expression of miR-128 was significantly suppressed in human breast cancer specimens. More importantly, its expression level was reversely correlated to histological grade of the cancer. Ectopic expression of miR-128 in the aggressive breast cancer cell line MDA-MB-231 could inhibit cell motility and invasive capacity remarkably. Afterwards, Metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric that implicated in various aspects of cancer progression and metastasis, was further identified as a direct target gene of miR-128 and its expression level was up-regulated in clinical samples as expected. Moreover, knockdown of MTDH in MDA-MB-231 cells obviously impaired the migration and invasion capabilities, whereas re-expression of MTDH abrogated the suppressive effect caused by miR-128.

CONCLUSIONS:

Overall, these findings demonstrate that miR-128 could serve as a novel biomarker for breast cancer metastasis and a potent target for treatment in the future.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / MicroRNAs / Neoplasm Invasiveness Type of study: Prognostic study Limits: Female / Humans Language: English Journal: Biol. Res Journal subject: Biology Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Fudan University Pudong Medical Center/CN / Shanghai Jiao Tong University School of Medicine/CN

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / MicroRNAs / Neoplasm Invasiveness Type of study: Prognostic study Limits: Female / Humans Language: English Journal: Biol. Res Journal subject: Biology Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Fudan University Pudong Medical Center/CN / Shanghai Jiao Tong University School of Medicine/CN