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Renal protective effects of vicenin-2 and scolymoside in a mouse model of sepsis
Lee, Bong-Seon; Yang, Sumin; Lee, Changhun; Ku, Sae-Kwang; Bae, Jong-Sup.
  • Lee, Bong-Seon; Kyungpook National University. BK21 Plus KNU Multi-Omics based Creative Drug Research Team. esearch Institute of Pharmaceutical Sciences. Daegu. KR
  • Yang, Sumin; Kyungpook National University. BK21 Plus KNU Multi-Omics based Creative Drug Research Team. esearch Institute of Pharmaceutical Sciences. Daegu. KR
  • Lee, Changhun; Kyungpook National University. BK21 Plus KNU Multi-Omics based Creative Drug Research Team. esearch Institute of Pharmaceutical Sciences. Daegu. KR
  • Ku, Sae-Kwang; Daegu Haany University. College of Korean Medicine. Department of Anatomy and Histology. Gyeongsan. KR
  • Bae, Jong-Sup; Kyungpook National University. BK21 Plus KNU Multi-Omics based Creative Drug Research Team. esearch Institute of Pharmaceutical Sciences. Daegu. KR
Braz. J. Pharm. Sci. (Online) ; 56: e18636, 2020. tab, graf
Article in English | LILACS | ID: biblio-1132060
ABSTRACT
This study was initiated to determine whether 2 structurally related flavonoids found in Cyclopia subternata-vicenin-2 (VCN) and scolymoside (SCL)-could modulate renal functional damage in a mouse model of sepsis, and to elucidate the relevant underlying mechanisms. The potential of VCN and SCL treatment to reduce renal damage induced by cecal ligation and puncture (CLP) surgery in mice was measured via assessment of serum creatinine, blood urea nitrogen (BUN), lipid peroxidation, total glutathione, glutathione peroxidase activity, catalase activity, and superoxide dismutase activity. Treatment with either VCN or SCL resulted in elevated plasma levels of BUN and creatinine, and of protein in the urine of mice with CLP-induced renal damage. Moreover, both VCN and SCL inhibited nuclear factor κB activation and reduced the induction of nitric oxide synthase and excessive production of nitric acid. VCN and SCL treatment also reduced the plasma levels of interleukin-6, and tumor necrosis factor-α, reduced lethality due to CLP-induced sepsis, increased lipid peroxidation, and markedly enhanced the antioxidant defense system by restoring the levels of superoxide dismutase, glutathione peroxidase, and catalase in kidney tissues. The present results suggest that VCN and SCL protect mice from sepsis-triggered renal injury
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Full text: Available Index: LILACS (Americas) Main subject: Flavonoids / Antioxidants Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2020 Type: Article Affiliation country: South Korea Institution/Affiliation country: Daegu Haany University/KR / Kyungpook National University/KR

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Full text: Available Index: LILACS (Americas) Main subject: Flavonoids / Antioxidants Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2020 Type: Article Affiliation country: South Korea Institution/Affiliation country: Daegu Haany University/KR / Kyungpook National University/KR