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The morphology of paca (Cuniculus paca) testis with high dose of letrozole an aromatase inhibitor / La morfología del testículo de paca (Cuniculus paca) con altas dosis de letrozol, un inhibidor de la aromatasa
Simões, Luciana Senna; Sasahara, Taís Harumi de Castro; Favaron, Phelipe Oliveira; Leal, Leonardo Martins; Oliveira, Fabrício Singaretti de; Fratini, Paula; Berger, Trish; Machado, Marcia Rita Fernandes; Miglino, Maria Angélica.
  • Simões, Luciana Senna; University of São Paulo. School of Veterinary Medicine and Animal Science. Department of Surgery. Sao Paulo. BR
  • Sasahara, Taís Harumi de Castro; University of São Paulo. School of Veterinary Medicine and Animal Science. Department of Surgery. Sao Paulo. BR
  • Favaron, Phelipe Oliveira; University of São Paulo. School of Veterinary Medicine and Animal Science. Department of Surgery. Sao Paulo. BR
  • Leal, Leonardo Martins; Uningá. Faculdade Ingá. Departamento de Medicina Veterinária. Maringá. BR
  • Oliveira, Fabrício Singaretti de; University of the State of São Paulo. Department of Animal Morphology and Physiology. Jaboticabal. BR
  • Fratini, Paula; University of São Paulo. School of Veterinary Medicine and Animal Science. Department of Surgery. Sao Paulo. BR
  • Berger, Trish; University of California. Department of Animal Science. US
  • Machado, Marcia Rita Fernandes; University of the State of São Paulo. Department of Animal Morphology and Physiology. Jaboticabal. BR
  • Miglino, Maria Angélica; University of São Paulo. School of Veterinary Medicine and Animal Science. Department of Surgery. Sao Paulo. BR
Int. j. morphol ; 38(6): 1525-1527, Dec. 2020. graf
Article in English | LILACS | ID: biblio-1134471
ABSTRACT

SUMMARY:

The study reported the influence of the high and acute dose of Letrozole on the testis morphology in paca (Cuniculus paca), an aromatase inhibitor that reduces the endogenous estrogen, the essential hormone for spermatogenesis. Morphological changes were observed in seminiferous epithelium with germ cells with apoptotic characteristics and presence of vacuoles and nuclei in pycnose.
RESUMEN
RESUMEN El objetivo de este estudio fue analizar la influencia de una dosis alta de Letrozol en la morfología de los testículos de la paca (Cuniculus paca), un inhibidor de la aromatasa que reduce el estrógeno endógeno, la hormona esencial para la espermatogénesis. Se observaron cambios morfológicos en el epitelio seminífero con células germinales con características apoptóticas y la presencia de vacuolas y núcleos en picnosis.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Testis / Aromatase Inhibitors / Cuniculidae / Letrozole Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2020 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Uningá/BR / University of California/US / University of São Paulo/BR / University of the State of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Testis / Aromatase Inhibitors / Cuniculidae / Letrozole Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2020 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Uningá/BR / University of California/US / University of São Paulo/BR / University of the State of São Paulo/BR