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Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats
Carminatti, Marina; Benetti, Francine; Siqueira, Renato Luiz; Zanotto, Edgar Dutra; Briso, André Luiz Fraga; Chaves-Neto, Antônio Hernandes; Cintra, Luciano Tavares Angelo.
  • Carminatti, Marina; Universidade Estadual Paulista. Faculdade de Odontologia de Araçatuba. Departamento de Odontologia Preventiva e Restauradora. Araçatuba. BR
  • Benetti, Francine; Universidade Estadual Paulista. Faculdade de Odontologia de Araçatuba. Departamento de Odontologia Preventiva e Restauradora. Araçatuba. BR
  • Siqueira, Renato Luiz; Universidade Federal de São Carlos. Departamento de Engenharia de Materiais. Laboratório de Materiais Vitreos. São Carlos. BR
  • Zanotto, Edgar Dutra; Universidade Federal de São Carlos. Departamento de Engenharia de Materiais. Laboratório de Materiais Vitreos. São Carlos. BR
  • Briso, André Luiz Fraga; Universidade Estadual Paulista. Faculdade de Odontologia de Araçatuba. Departamento de Odontologia Preventiva e Restauradora. Araçatuba. BR
  • Chaves-Neto, Antônio Hernandes; Universidade Estadual Paulista. Faculdade de Odontologia de Araçatuba. Departamento de Ciências Básicas. Araçatuba. BR
  • Cintra, Luciano Tavares Angelo; Universidade Estadual Paulista. Faculdade de Odontologia de Araçatuba. Departamento de Odontologia Preventiva e Restauradora. Araçatuba. BR
J. appl. oral sci ; 28: e20190384, 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1134801
ABSTRACT
Abstract Objectives This study evaluated if the use of a bioactive glass-ceramic-based gel, named Biosilicate (BS), before, after or mixed with bleaching gel, could influence the inflammation of the dental pulp tissue of rats' molars undergoing dental bleaching with hydrogen peroxide (H2O2). Methodology The upper molars of Wistar rats (Rattus norvegicus, albinus) were divided into Ble bleached (35% H2O2, 30-min); Ble-BS bleached and followed by BS-based gel application (20 min); BS-Ble BS-based gel application and then bleaching; BS/7d-Ble BS-based gel applications for 7 days and then bleaching; Ble+BS blend of H2O2 with BS-based gel (11, 30-min); and control placebo gel. After 2 and 30 days (n=10), the rats were euthanized for histological evaluation. The Kruskal-Wallis and Dunn statistical tests were performed (P<0.05). Results At 2 days, the Ble and Ble-BS groups had significant alterations in the pulp tissue, with an area of necrosis. The groups with the application of BS-based gel before H2O2 had moderate inflammation and partial disorganization in the occlusal third of the coronary pulp and were significantly different from the Ble in the middle and cervical thirds (P<0.05). The most favorable results were observed in the Ble+BS, which was similar to the control in all thirds of the coronary pulp (P>0.05). At 30 days, the pulp tissue was organized and the bleached groups presented tertiary dentin deposition. The Ble group had the highest deposition of tertiary dentin, followed by the Ble-BS, and both were different from control (P<0.05). Conclusion A single BS-based gel application beforehand or BS-based gel blended with a bleaching gel minimize the pulp damage induced by dental bleaching.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pulpitis / Tooth Bleaching / Dental Pulp / Tooth Bleaching Agents / Glass / Hydrogen Peroxide Type of study: Evaluation studies Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR / Universidade Federal de São Carlos/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pulpitis / Tooth Bleaching / Dental Pulp / Tooth Bleaching Agents / Glass / Hydrogen Peroxide Type of study: Evaluation studies Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR / Universidade Federal de São Carlos/BR