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Abnormal thymic stromal lymphopoietin expression in the gastrointestinal mucosa of patients with eosinophilic gastroenteritis / Expressão anormal da linfopoietina estromal tímica na mucosa gastrointestinal depacientes com gastroenterite e osinofílica
Guo, Hongmei; Ji, Xiaolan; Yang, Guang; Jin, Yu.
  • Guo, Hongmei; Nanjing Medical University. Childrens Hospital Affiliated. Department of Gastroenterology. Nanjing. CN
  • Ji, Xiaolan; Nanjing Medical University. Childrens Hospital Affiliated. Department of Gastroenterology. Nanjing. CN
  • Yang, Guang; Nanjing Medical University. Childrens Hospital Affiliated. Department of Gastroenterology. Nanjing. CN
  • Jin, Yu; Nanjing Medical University. Childrens Hospital Affiliated. Department of Gastroenterology. Nanjing. CN
J. pediatr. (Rio J.) ; 96(3): 350-355, May-June 2020. tab, graf
Article in English | LILACS, ColecionaSUS, SES-SP | ID: biblio-1135027
ABSTRACT
Abstract

Objective:

To investigate the differential expression of the thymic stromal lymphopoietin isoforms, short and long, and discern their biological implications under eosinophilic gastroenteritis.

Methods:

The expression of thymic stromal lymphopoietin and its two isoforms in tissues was assessed by quantitative RT-PCR in healthy controls (n = 24) and patients with eosinophilic gastroenteritis (n = 17).

Results:

Thymic stromal lymphopoietin mRNA was significantly reduced in eosinophilic gastroenteritis when compared with healthy controls (p < 0.0001). A significantly lower amount of short thymic stromal lymphopoietin mRNA was observed in eosinophilic gastroenteritis when compared with controls (p < 0.05), while a significantly higher amount of long thymic stromal lymphopoietin mRNA was observed in eosinophilic gastroenteritis when compared with controls (p < 0.05). Peak eosinophilic count is significantly positively correlated with the expression of long thymic stromal lymphopoietin mRNA in the gastrointestinal mucosal of patients with eosinophilic gastroenteritis (r s = 0.623, p < 0.005), while peak eosinophilic count is significantly negatively correlated with the expression of short thymic stromal lymphopoietin mRNA in the gastrointestinal mucosal of patients with eosinophilic gastroenteritis (r s = −0.4474, p < 0.05).

Conclusions:

Abnormal mucosal thymic stromal lymphopoietin expression may contribute to gastrointestinal mucosa damage in eosinophilic gastroenteritis.
RESUMO
Resumo

Objetivo:

Investigar a expressão diferencial das isoformas da linfopoietina estromal tímica, curta e longa, e discernir suas implicações biológicas na gastroenterite eosinofílica.

Métodos:

Avaliamos a expressão das isoformas da linfopoietina estromal tímica e suas duas isoformas através da técnica RT-PCR quantitativa em tecidos de controles saudáveis (n = 24) e pacientes com gastroenterite eosinofílica (n = 17).

Resultados:

Demonstramos que o RNAm das isoformas da linfopoietina estromal tímica estava significativamente reduzido na gastroenterite eosinofílica em comparação com os controles saudáveis (p < 0,0001). Também descobrimos uma quantidade significativamente menor de RNAm das isoformas da linfopoietina estromal tímica curta na gastroenterite eosinofílica em comparação com os controles (p < 0,05) e uma quantidade significativamente maior de RNAm das isoformas da linfopoietina estromal tímica longa na gastroenterite eosinofílica em comparação com os controles (p < 0,05). O pico da contagem eosinofílica está correlacionado positiva e significativamente com a expressão do RNAm das isoformas da linfopoietina estromal tímica longa na mucosa gastrointestinal de pacientes com gastroenterite eosinofílica (rs = 0,623, p < 0,005), enquanto o pico de contagem eosinofílica está negativa e significativamente correlacionado com a expressão do RNAm das isoformas da linfopoietina estromal tímica curta na mucosa gastrointestinal de pacientes com gastroenterite eosinofílica (rs = -0,4474, p < 0,05).

Conclusões:

A expressão anormal das isoformas da linfopoietina estromal tímica na mucosa pode contribuir para o dano da mucosa gastrointestinal na gastroenterite eosinofílica.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Enteritis / Eosinophilia / Gastritis Limits: Humans Language: English Journal: J. pediatr. (Rio J.) Year: 2020 Type: Article Institution/Affiliation country: Nanjing Medical University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Enteritis / Eosinophilia / Gastritis Limits: Humans Language: English Journal: J. pediatr. (Rio J.) Year: 2020 Type: Article Institution/Affiliation country: Nanjing Medical University/CN