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Pharmacological therapy and cardiovascular risk reduction for type 2 diabetes
Martins, Eduardo Bello; Lima, Eduardo Gomes; Pitta, Fábio Grunspun; Carvalho, Leticia Neves Solon; Queiroz, Thiago Dias de; Serrano Júnior, Carlos Vicente.
  • Martins, Eduardo Bello; USP. Faculdade de Medicina. Hospital das Clínicas. BR
  • Lima, Eduardo Gomes; USP. Faculdade de Medicina. Hospital das Clínicas. BR
  • Pitta, Fábio Grunspun; USP. Faculdade de Medicina. Hospital das Clínicas. BR
  • Carvalho, Leticia Neves Solon; USP. Faculdade de Medicina. Hospital das Clínicas. BR
  • Queiroz, Thiago Dias de; USP. Faculdade de Medicina. Hospital das Clínicas. BR
  • Serrano Júnior, Carlos Vicente; USP. Faculdade de Medicina. Hospital das Clínicas. BR
Rev. Assoc. Med. Bras. (1992) ; 66(9): 1283-1288, Sept. 2020. tab, graf
Article in English | SES-SP, LILACS | ID: biblio-1136379
ABSTRACT
SUMMARY The pharmacological therapy for type 2 diabetes mellitus has presented important advances in recent years, which has impacted the treatment of patients with established cardiovascular disease or with high cardiovascular risk. In this scenario, two drug classes have emerged and demonstrated clear clinical benefits SGLT-2 inhibitors and GLP-1 agonists. The present review discusses the pharmacology, adverse effects, and clinical trials that have demonstrated the benefits of these medications in reducing cardiovascular risk.
RESUMO
RESUMO A terapia farmacológica do diabetes mellitus tipo 2 apresentou avanços importantes nos últimos anos, impactando principalmente o tratamento dos pacientes com doença cardiovascular estabelecida ou com alto risco cardiovascular. Nesse cenário, surgiram duas classes de fármacos com claros benefícios clínicos; os inibidores da SGLT-2 e os agonistas do GLP-1. Na presente revisão os autores discutem desde a farmacologia, efeitos adversos e também os estudos clínicos que demonstraram os benefícios dessas medicações na redução de risco cardiovascular.
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Full text: Available Index: LILACS (Americas) Main subject: Cardiovascular Diseases / Diabetes Mellitus, Type 2 Type of study: Etiology study / Risk factors Limits: Humans Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2020 Type: Article Institution/Affiliation country: USP/BR

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Full text: Available Index: LILACS (Americas) Main subject: Cardiovascular Diseases / Diabetes Mellitus, Type 2 Type of study: Etiology study / Risk factors Limits: Humans Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2020 Type: Article Institution/Affiliation country: USP/BR