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Preparation of Coronavirus nosodes sourced from a clinical sample of SARS-Cov-2 positive patient, inactivated strain, and spike glycoprotein
Mukherjee, Sandeepan; Talele, Gitanjali; Chowdhary, Abhay; Vaidya, Shashikant; Deshmukh, Rajesh; Rawal, Rakesh; Shah, Rajesh.
  • Mukherjee, Sandeepan; S.AF.
  • Talele, Gitanjali; S.AF.
  • Chowdhary, Abhay; S.AF.
  • Vaidya, Shashikant; S.AF.
  • Deshmukh, Rajesh; S.AF.
  • Rawal, Rakesh; S.AF.
  • Shah, Rajesh; S.AF.
Int. j. high dilution res ; 19(4): 2-9, 2020.
Article in English | LILACS, HomeoIndex | ID: biblio-1146533
ABSTRACT
IntroductionNosodes, the homeopathicpreparationssourcedfrom biological materials including clinical samples, cultures of organisms, and diseased tissues have been in use against the source-specific infections as well as other diseases. The nosodes have demonstrated some efficacy in managing epidemics, such as influenza, dengue, and leptospirosis.This article presents the need and process of development ofnosodes from the SARS-CoV-2 to explore its prophylactic and therapeutic potentials against certain related viral diseases.Materials and methodsA clinical sample of SARS-Cov-2 positive patient,based on the cycle threshold (CT) value of the qRT-PCR, heat-inactivated SARS-CoV-2, and spike glycoprotein all were processed for making nosodesas per the method described in Homoeopathy Pharmacopoeia of India.Molecular tests, such as qRT-PCR and sterility tests were performed to establish the live organisms, RNA material, and the absence of contamination.ResultsThree variants of CoronavirusNosodewere developed using a clinical sample,heat-inactivatedSARS-CoV-2, and spike glycoprotein.In potencies 3c and above, no detectableSARS-CoV-2 RNA material was found by PCR.The analytical results for nosodes were reported as compliant for sterility testing as per the IP.ConclusionThree variants of Coronavirus nosodes were preparedwhich need to be evaluated further through pre-clinical and clinical studies.(AU)
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Nosodes in Homeopathy / Coronavirus Infections / Drug Compounding / Spike Glycoprotein, Coronavirus / Betacoronavirus Limits: Humans Language: English Journal: Int. j. high dilution res Journal subject: Homeopathy / Terapias Complementares Year: 2020 Type: Article

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Full text: Available Index: LILACS (Americas) Main subject: Nosodes in Homeopathy / Coronavirus Infections / Drug Compounding / Spike Glycoprotein, Coronavirus / Betacoronavirus Limits: Humans Language: English Journal: Int. j. high dilution res Journal subject: Homeopathy / Terapias Complementares Year: 2020 Type: Article