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Is there a clinical pathological correlation of colorectal adenocarcinoma with the immunohistochemical expression of opn and abcb5? / Há correlação clínicopatológica do adenocarcinoma colorretal com a expressão imunoistoquímica do opn e abcb5?
Castoldi, Diogo Francesco; Malafaia, Osvaldo; Santos-Neto, Pedro Helo dos; Postiglioni, Tatiana Varella; Vasconcelos, Cecilia; Bremer, Fabiola Past; Czeczko, Leticia Elizabeth Augustin; Gasser, Martin; Waaga-Gasser, Ana Maria; Ribas, Carmen Australia Paredes Marcondes.
  • Castoldi, Diogo Francesco; Mackenzie Evangelical School of Paraná. Medical Research Institute. Curitiba. BR
  • Malafaia, Osvaldo; Mackenzie Evangelical School of Paraná. Medical Research Institute. Curitiba. BR
  • Santos-Neto, Pedro Helo dos; Mackenzie Evangelical School of Paraná. Curitiba. BR
  • Postiglioni, Tatiana Varella; Mackenzie Evangelical School of Paraná. Curitiba. BR
  • Vasconcelos, Cecilia; Mackenzie Evangelical School of Paraná. Department of Hematology. Curitiba. BR
  • Bremer, Fabiola Past; Mackenzie Evangelical School of Paraná. Department of Oncology. Curitiba. BR
  • Czeczko, Leticia Elizabeth Augustin; Mackenzie Evangelical School of Paraná. Department of Hematology. Curitiba. BR
  • Gasser, Martin; University Hospital Würzburg. Department of Surgery. Würzburg. DE
  • Waaga-Gasser, Ana Maria; Harvard Medical School. Brigham and Womans Hospital. Renal Division. Boston. US
  • Ribas, Carmen Australia Paredes Marcondes; Mackenzie Evangelical School of Paraná. Medical Research Institute. Curitiba. BR
ABCD (São Paulo, Impr.) ; 33(4): e1569, 2020. tab, graf
Article in English | LILACS | ID: biblio-1152636
ABSTRACT
ABSTRACT

Background:

Studies with biomarkers in TMA (tissue microarray) have been showing important results regarding its expression in colon cancer.

Aim:

Correlate the expression profile of the OPN and ABCB5 biomarkers with the epidemiological and clinicopathological characteristics of the patients, the impact on the progression of the disease and the death.

Method:

A total of 122 CRC patients who underwent surgical resection, immunomarking and their relationship with progression and death events were evaluated.

Result:

The average age was 61.9 (±13.4) years. The cases were distributed in 42 (35.9%) in the ascending/transverse colon, 31 (26.5%) in the sigmoid, 27 in the rectum (23.1%), 17 (14.5%) in the descending colon. Most patients had advanced disease (stages III and IV) in 74 cases (60.9%). There was a predominance of moderately differentiated tumors in 101 samples (82.8%); despite this, the poorly differentiated subtype proved to be an independent risk factor for death in 70%. Metastasis to the liver proved to be an independent risk factor for death in 75% (18/24), as well as patients with primary rectal tumors in 81.5% (22/27).

Conclusion:

The immunohistochemical expression of the OPN and ABCB5 markers was not associated with epidemiological and clinicopathological characteristics. Regarding the progression of disease and death, it was not possible to observe a correspondence relationship with the evaluated markers.
RESUMO
RESUMO Racional Estudos com biomarcadores com TMA (tissue microarray) vêm demostrando resultados importantes em relação à expressão de biomarcadores em câncer de cólon.

Objetivo:

Correlacionar o perfil de expressão dos biomarcadores OPN e ABCB5 com as características epidemiológicas e clinicopatológicas dos pacientes, o impacto na progressão de doença e no evento óbito.

Método:

Foram avaliados 122 pacientes de CCR submetidos à ressecção cirúrgica e à imunomarcação e relação com os eventos progressão e óbito.

Resultado:

A média de idade encontrada foi de 61,9 (±13,4) anos. Os casos distribuíram-se em 42 (35,9%) no cólon ascendente/transverso, 31 (26,5%) no sigmoide, 27 no reto (23,1%), 17 (14,5%) no cólon descendente. A maioria dos pacientes apresentou doença avançada (estadio III e IV) em 74 casos (60,9%). Houve predomínio de tumor moderadamente diferenciado em 101 amostras (82,8%); apesar disso, o subtipo pouco diferenciado mostrou-se como fator de risco independente para óbito em 70% dos casos. Metástase para o fígado mostrou-se fator de risco independente para óbito em 75% dos casos (18/24), assim como pacientes com tumores primários de reto em 81,5% (22/27).

Conclusão:

A expressão imunoistoquímica dos marcadores OPN e ABCB5 não apresentou associação com as características epidemiológicas e clinicopatológicas. Em relação à progressão de doença e evento óbito, não se conseguiu observar relação de correspondência com os marcadores avaliados.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Colorectal Neoplasms / Adenocarcinoma / Colonic Neoplasms / ATP Binding Cassette Transporter, Subfamily B Type of study: Prognostic study / Risk factors Limits: Humans Language: English Journal: ABCD (São Paulo, Impr.) Year: 2020 Type: Article Affiliation country: Brazil / Germany / United States Institution/Affiliation country: Harvard Medical School/US / Mackenzie Evangelical School of Paraná/BR / University Hospital Würzburg/DE

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Full text: Available Index: LILACS (Americas) Main subject: Colorectal Neoplasms / Adenocarcinoma / Colonic Neoplasms / ATP Binding Cassette Transporter, Subfamily B Type of study: Prognostic study / Risk factors Limits: Humans Language: English Journal: ABCD (São Paulo, Impr.) Year: 2020 Type: Article Affiliation country: Brazil / Germany / United States Institution/Affiliation country: Harvard Medical School/US / Mackenzie Evangelical School of Paraná/BR / University Hospital Würzburg/DE