Effects of Curcumin on Sodium Arsenite Induced Neoplastic Cell Transformation in Balb/c 3T3 Cells

Demircioglu, Busra; Aydin, Yasemin; Orta-Yilmaz, Banu; Yildizbayrak, Nebahat; Erkan, Melike

Demircioglu, Busra; Aydin, Yasemin; Orta-Yilmaz, Banu; Yildizbayrak, Nebahat; Erkan, Melike.

Demircioglu, Busra; Istanbul University. Institute of Graduate Studies in Sciences. Department of Biology. Istanbul. TR
Aydin, Yasemin; Istanbul University. Faculty of Science. Department of Biology. Istanbul. TR
Orta-Yilmaz, Banu; Istanbul University. Faculty of Science. Department of Biology. Istanbul. TR
Yildizbayrak, Nebahat; Istanbul University. Faculty of Science. Department of Biology. Istanbul. TR
Erkan, Melike; Istanbul University. Faculty of Science. Department of Biology. Istanbul. TR

Braz. arch. biol. technol ; 64: e21200093, 2021. tab, graf

Article in English | LILACS | ID: biblio-1153294

ABSTRACT

ABSTRACT

HIGHLIGHTS Sodium arsenite can cause neoplastic transformation in cells. Curcumin reduced cell viability and increased LDH activity in transformed Balb/c 3T3 cells. Curcumin caused DNA damage in transformed Balb/c 3T3 cells. Curcumin may play a protective role in sodium arsenite-induced toxicity.

Subject(s)

Animals; Mice; Arsenic/toxicity; DNA Damage; Cell Transformation, Neoplastic; Curcumin/pharmacology; Fibroblasts/drug effects; BALB 3T3 Cells; Fibroblasts/pathology

Cancer; Curcumin; Embryonic fibroblast cells; Genotoxicity; Sodium arsenite

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Full text: Available Index: LILACS (Americas) Main subject: Arsenic / DNA Damage / Cell Transformation, Neoplastic / Curcumin / Fibroblasts Limits: Animals Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Istanbul University/TR

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