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Down-regulation of HCP5 inhibits cell proliferation, migration, and invasion through regulating EPHA7 by competitively binding miR-101 in osteosarcoma
Tu, Yangmao; Cai, Qing; Zhu, Xuemei; Xu, Min.
  • Tu, Yangmao; Jingzhou Hospital of Traditional Chinese Medicine. Department of Orthopedics. Jingzhou. CN
  • Cai, Qing; Jingzhou Hospital of Traditional Chinese Medicine. Department of Orthopedics. Jingzhou. CN
  • Zhu, Xuemei; Jingzhou Hospital of Traditional Chinese Medicine - Functional Section. Jingzhou. CN
  • Xu, Min; Jingzhou Institute of Technology, College of Textile and Apparel Design and Art. Jingzhou. CN
Braz. j. med. biol. res ; 54(2): e9161, 2021. graf
Article in English | LILACS | ID: biblio-1153511
ABSTRACT
Patients with osteosarcoma (OS) usually have poor overall survival because of frequent metastasis. Long non-coding RNAs (lncRNAs) have been reported to be associated with tumorigenesis and metastasis. In this study, we investigated the expression and roles of lncRNA human histocompatibility leukocyte antigen (HLA) complex P5 (HCP5) in OS, aiming to provide a novel molecular mechanism for OS. HCP5 was up-regulated both in OS tissues and cell lines and high expression of HCP5 was associated to low survival in OS patients. Down-regulation of HCP5 inhibited cell proliferation, migration, and invasion, suggesting its carcinogenic role in OS. miR-101 was targeted by HCP5 and its expression was decreased in OS. The inhibitor of miR-101 reversed the impact of HCP5 down-regulation on cell proliferation, apoptosis, and metastasis in OS. Ephrin receptor 7 (EPHA7) was proved to be a target of miR-101 and had ability to recover the effects of miR-101 inhibitor in OS. In conclusion, lncRNA HCP5 knockdown suppressed cell proliferation, migration, and invasion, and induced apoptosis through depleting the expression of EPHA7 by binding to miR-101, providing a potential therapeutic strategy of HCP5 in OS.
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Full text: Available Index: LILACS (Americas) Main subject: Bone Neoplasms / Osteosarcoma / MicroRNAs / RNA, Long Noncoding Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Jingzhou Hospital of Traditional Chinese Medicine - Functional Section/CN / Jingzhou Hospital of Traditional Chinese Medicine/CN / Jingzhou Institute of Technology, College of Textile and Apparel Design and Art/CN

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Full text: Available Index: LILACS (Americas) Main subject: Bone Neoplasms / Osteosarcoma / MicroRNAs / RNA, Long Noncoding Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Jingzhou Hospital of Traditional Chinese Medicine - Functional Section/CN / Jingzhou Hospital of Traditional Chinese Medicine/CN / Jingzhou Institute of Technology, College of Textile and Apparel Design and Art/CN