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Predictors of functional capacity as measured by the Glittre activities of daily living test in women with rheumatoid arthritis
Palugan, M J A; Assis, A C B; Bessa, E J C; Ferreira, A S; Lopes, A J.
  • Palugan, M J A; Centro Universitário Augusto Motta. Programa de Pós-Graduação em Ciências da Reabilitação. Rio de Janeiro. BR
  • Assis, A C B; Centro Universitário Augusto Motta. Programa de Pós-Graduação em Ciências da Reabilitação. Rio de Janeiro. BR
  • Bessa, E J C; Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Programa de Pós-Graduação em Ciências Médicas. Rio de Janeiro. BR
  • Ferreira, A S; Centro Universitário Augusto Motta. Programa de Pós-Graduação em Ciências da Reabilitação. Rio de Janeiro. BR
  • Lopes, A J; Centro Universitário Augusto Motta. Programa de Pós-Graduação em Ciências da Reabilitação. Rio de Janeiro. BR
Braz. j. med. biol. res ; 54(5): e10040, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153551
ABSTRACT
Although pulmonary involvement is the most common extra-articular manifestation of rheumatoid arthritis (RA), traditional pulmonary function tests (PFTs) do not show a good correlation with the field tests usually performed in these patients. In recent decades, measurement of ventilation distribution heterogeneity through the nitrogen single-breath washout (N2SBW) test and evaluation of functional capacity during exercise using the Glittre activities of daily living test (GA-T) have been increasingly used. Therefore, the objective of this study was to evaluate predictors of GA-T outcomes in women with RA considering demographic, anthropometric, clinical, functional variables, and chest computed tomography (CT) findings. Forty-three women with RA underwent the GA-T, the N2SBW test, spirometry, measurement of the diffusing capacity for carbon monoxide (DLco), measurement of respiratory muscle strength, and evaluation of physical function of the lower and upper limbs through the Health Assessment Questionnaire Disability Index (HAQ-DI). Chest CT scans were analyzed retrospectively. The GA-T time showed significant correlations with the DLco (rs=-0.397, P=0.008), forced vital capacity/DLco (rs=0.307, P=0.044), phase III slope of the N2SBW test (SIIIN2, rs=0.644, P<0.0001), and the HAQ-DI (rs=0.482, P=0.001). Disease extent as assessed by chest CT was associated with the GA-T time. On multiple regression analysis, the SIIIN2 and HAQ-DI were the only predictors of the GA-T time, explaining 40% of its variability. Thus, ventilation distribution heterogeneity and worse physical function substantially explain the variability in GA-T time in women with RA and varying extents of disease on chest CT.
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Full text: Available Index: LILACS (Americas) Main subject: Arthritis, Rheumatoid / Activities of Daily Living Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Universitário Augusto Motta/BR / Universidade do Estado do Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Arthritis, Rheumatoid / Activities of Daily Living Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro Universitário Augusto Motta/BR / Universidade do Estado do Rio de Janeiro/BR