Your browser doesn't support javascript.
loading
Radiotherapy for early and advanced stages Follicular Lymphoma
Mauro, Geovanne Pedro; Medici, Carolina Trindade Mello; Casimiro, Lucas Coelho; Weltman, Eduardo.
  • Mauro, Geovanne Pedro; Faculdade de Medicina (FMUSP), Universidade de Sao Paulo. Departamento de Radiologia e Oncologia. Sao Paulo. BR
  • Medici, Carolina Trindade Mello; Hospital do Cancer de Barretos. Departamento de Radioterapia. Porto Velho. BR
  • Casimiro, Lucas Coelho; Universidade de Sao Paulo. Departamento de Radioterapia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Faculdade de Medicina (FMUSP). Sao Paulo. BR
  • Weltman, Eduardo; Faculdade de Medicina (FMUSP), Universidade de Sao Paulo. Departamento de Radiologia e Oncologia. Sao Paulo. BR
Clinics ; 76: e2059, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153970
ABSTRACT
OBJECTIVES To evaluate the results of radiotherapy (RT) for follicular lymphoma (FL) under different management scenarios. METHODS We retrospectively assessed consecutive patients with FL who had undergone irradiation between 2010 and 2018. All patients had biopsy-proven FL and were positron emission tomography-staged, although some (35.3%) were reassessed with computed tomography after treatment alone. Rituximab was only available to FL patients after 2016. RESULTS Thirty-four patients were selected, with a mean age at diagnosis of 61.6 years (34-89 years). The median follow-up duration was 49.4 months. Most patients were female (58.8%) and showed good performance on the Eastern Cooperative Oncology Group (ECOG) scale (ECOG 0-55.9%). The mean overall survival (OS) and progression-free survival were 48.7 and 33.6 months, respectively, with four deaths reported. OS rates at 2 and 3 years were 94.1% and 91.2%, respectively. Four patients showed transformation into aggressive lymphomas and underwent rituximab-based systemic treatment. Transformation-free survival was 47.8 months, and all patients with transformed disease were alive at assessment. Five patients had in-field relapse, all of them also relapsed elsewhere, and the mean relapse-free survival time was 40.3 months. No median end points were reached on assessment. CONCLUSION FL is an indolent disease. Our findings show good outcomes for patients treated with radiation, with a low transformation rate and excellent management of relapsed disease. RT is an important part of these results.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Lymphoma, Follicular Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina (FMUSP), Universidade de Sao Paulo/BR / Hospital do Cancer de Barretos/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Lymphoma, Follicular Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculdade de Medicina (FMUSP), Universidade de Sao Paulo/BR / Hospital do Cancer de Barretos/BR