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COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19?
Daisley Jr, Hubert; Rampersad, Arlene; Daisley, Martina; Ramdin, Amit; Acco, Oneka; Narinesingh, Farhaana; Humphrey, Ornella.
  • Daisley Jr, Hubert; General Hospital San Fernando. Department of Pathology. West Indies. TT
  • Rampersad, Arlene; General Hospital San Fernando. Department of Pathology. West Indies. TT
  • Daisley, Martina; Scarborough General Hospital. Department of Accident and Emergency. West Indies. TT
  • Ramdin, Amit; General Hospital San Fernando. Department of Pathology. West Indies. TT
  • Acco, Oneka; General Hospital San Fernando. Department of Pathology. West Indies. TT
  • Narinesingh, Farhaana; General Hospital San Fernando. Department of Pathology. West Indies. TT
  • Humphrey, Ornella; University of the West Indies. Trinidad. TT
Autops. Case Rep ; 11: e2021262, 2021. graf
Article in English | LILACS | ID: biblio-1249006
ABSTRACT
We performed autopsies on two cases of COVID-19. The microcirculations of all organs were the site of the pathological findings. Thrombotic microangiopathy was found in the brain and also the kidneys. Vasculitis was also a feature of the autopsy findings, together with portal triaditis of the liver. The major pathological findings in both cases were fibrin deposits. Within the lung, the fibrin deposits were observed in the alveolar microcirculation in sub-endothelial locations of capillaries, arterioles, post capillary venules, and the adventitia of larger vessels. These fibrin deposits in the lungs occurred at the sites where pericytes are located in these vessels. The pericyte with its high concentration of ACE-2 receptors and its procoagulant state may represent one of the primary sites of action of SARS-CoV-2. A review of pericytes in health and disease is undertaken. COVID-19 is a disease of the microcirculation.
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Full text: Available Index: LILACS (Americas) Main subject: Pericytes / SARS-CoV-2 / Microcirculation Limits: Adolescent / Aged / Aged80 / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: Trinidad and Tobago Institution/Affiliation country: General Hospital San Fernando/TT / Scarborough General Hospital/TT / University of the West Indies/TT

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Full text: Available Index: LILACS (Americas) Main subject: Pericytes / SARS-CoV-2 / Microcirculation Limits: Adolescent / Aged / Aged80 / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: Trinidad and Tobago Institution/Affiliation country: General Hospital San Fernando/TT / Scarborough General Hospital/TT / University of the West Indies/TT