COVID-19: a closer look at the pathology in two autopsied cases. Is the pericyte at the center of the pathological process in COVID-19?
Autops. Case Rep
;
11: e2021262, 2021. graf
Article
in English
| LILACS
| ID: biblio-1249006
ABSTRACT
We performed autopsies on two cases of COVID-19. The microcirculations of all organs were the site of the pathological findings. Thrombotic microangiopathy was found in the brain and also the kidneys. Vasculitis was also a feature of the autopsy findings, together with portal triaditis of the liver. The major pathological findings in both cases were fibrin deposits. Within the lung, the fibrin deposits were observed in the alveolar microcirculation in sub-endothelial locations of capillaries, arterioles, post capillary venules, and the adventitia of larger vessels. These fibrin deposits in the lungs occurred at the sites where pericytes are located in these vessels. The pericyte with its high concentration of ACE-2 receptors and its procoagulant state may represent one of the primary sites of action of SARS-CoV-2. A review of pericytes in health and disease is undertaken. COVID-19 is a disease of the microcirculation.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pericytes
/
SARS-CoV-2
/
Microcirculation
Limits:
Adolescent
/
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2021
Type:
Article
Affiliation country:
Trinidad and Tobago
Institution/Affiliation country:
General Hospital San Fernando/TT
/
Scarborough General Hospital/TT
/
University of the West Indies/TT
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