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De novo double-hit B-cell precursor leukemia/lymphoma - an unusual presentation as peritoneal lymphomatosis
Thirunavukkarasu, Balamurugan; Samanta, Jayanta; Bhatia, Prateek; Bal, Amanjit.
  • Thirunavukkarasu, Balamurugan; Post Graduate Institute of Medical Education & Research. Departments of Histopathology. Chandigarh. IN
  • Samanta, Jayanta; Post Graduate Institute of Medical Education & Research. Department of Gastroenterology. Chandigarh. IN
  • Bhatia, Prateek; Post Graduate Institute of Medical Education & Research. Department of Pediatrics. Chandigarh. IN
  • Bal, Amanjit; Post Graduate Institute of Medical Education & Research. Departments of Histopathology. Chandigarh. IN
Autops. Case Rep ; 11: e2021278, 2021. graf
Article in English | LILACS | ID: biblio-1249013
ABSTRACT
Peritoneal lymphomatosis (PL) is a rare presentation of extranodal precursor leukemia/lymphoma. The presentation is often non-specific, leading to delayed diagnosis and treatment. In this case, though the preliminary diagnosis was established on ascitic fluid cytology, the disease progressed rapidly, leading to demise before initiating chemotherapy. Immunophenotyping and molecular studies, performed later, established a diagnosis of de novo B-cell precursor leukemia/lymphoma with MYC, BCL2 rearrangements (Double-hit lymphoma). MYC, BCL2 rearrangements are rarely reported in precursor B-lymphoma/leukemia which carry dismal prognosis. In this report, we illustrate autopsy findings of PL in an elderly gentleman who presented with ascites for evaluation.
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Full text: Available Index: LILACS (Americas) Main subject: Peritoneal Neoplasms / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Type of study: Prognostic study Limits: Aged / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: India Institution/Affiliation country: Post Graduate Institute of Medical Education & Research/IN

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Full text: Available Index: LILACS (Americas) Main subject: Peritoneal Neoplasms / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Type of study: Prognostic study Limits: Aged / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: India Institution/Affiliation country: Post Graduate Institute of Medical Education & Research/IN