Recombinant human insulin-like growth factor-1 promotes osteoclast formation and accelerates orthodontic tooth movement in rats
J. appl. oral sci
;
29: e20200791, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1250185
ABSTRACT
Abstract Background:
IGF-1 may be an important factor in bone remodeling, but its mechanism of action on osteoclasts during orthodontic tooth movement is complex and unclear.Methodology:
The closed-coil spring was placed between the left maxillary first molar and upper incisors with a force of 50 g to establish an orthodontic movement model. Eighty SD rats were randomized to receive phosphate buffer saline or 400 ng rhIGF-1 in the lateral buccal mucosa of the left maxillary first molar every two days. Tissue sections were stained for tartrate-resistant acidic phosphatase (TRAP), the number of TRAP-positive cells was estimated and tooth movement measured.Results:
The rhIGF-1 group exhibited evidential bone resorption and lacuna appeared on the alveolar bone compared to the control group. Moreover, the number of osteoclasts in compression side of the periodontal ligament in the rhIGF-1 group peaked at day 4 (11.37±0.95 compared to 5.28±0.47 in the control group) after the orthodontic force was applied and was significantly higher than that of the control group (p<0.01). Furthermore, the distance of tooth movement in the rhIGF-1 group was significantly larger than that of the control group from day 4 to day 14 (p<0.01), suggesting that rhIGF-1 accelerated orthodontic tooth movement.Conclusion:
Our study has showed that rhIGF-1 could stimulate the formation of osteoclasts in the periodontal ligament, and accelerate bone remodeling and orthodontic tooth movement.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Osteoclasts
/
Tooth Movement Techniques
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2021
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Guangdong Province Stomatological Hospital/CN
/
Guiyang Stomatological Hospital Affiliated to Zunyi Medical University/CN
/
Guizhou Province Peoples Hospital/CN
/
Shenzhen Ai Kang Jian Stomatological Hospital/CN
/
Special Key Laboratory of Oral Diseases Research from Higher Education Institution of Guizhou Province & Zunyi Key Laboratory of Oral Disease Research/CN
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