Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study
São Paulo med. j
;
139(3): 279-284, May-June 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1252247
ABSTRACT
ABSTRACT BACKGROUND:
Vitamin D has relationships with pathogenesis and inflammation pathways in many diseases. Its deficiency may make clinicians think not only of supplementation but also of presence of other diseases.OBJECTIVE:
To investigate the relationship between vitamin D levels and deep vein thrombosis (DVT), given that reduced levels are related to increased risk of cardiovascular diseases. DESIGN ANDSETTING:
Case-control study conducted in the cardiovascular surgery and family medicine departments of a hospital in Turkey.METHODS:
A total of 280 participants were included 140 each in the DVT and control groups. Basic clinical characteristics, comorbidities and serum 25-hydroxyvitamin D (25(OH)D) levels were recorded and then compared between the groups. Serum 25(OH)D levels were also evaluated separately in three subgroups (sufficient, insufficient and deficient).RESULTS:
Serum 25(OH)D levels were significantly lower in the DVT group than in the controls (P < 0.001). Females in the DVT group had lower 25(OH)D levels than those in the control group (P = 0.002). Nonetheless, the median 25(OH)D level (16.41 ng/ml) of the control group was still below the reference value. Logistic regression analysis showed that 25(OH)D was a significant predictor of DVT. Weight, height and body mass index, which all presented interaction, were significant in the logistic regression analysis but not in individual analyses.CONCLUSION:
The serum vitamin D levels of DVT patients were lower than those of controls. If the results obtained from our study are supported by further large-scale randomized controlled trials, vitamin D replacement may be brought into the agenda for protection against DVT.
Full text:
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Index:
LILACS (Americas)
Main subject:
Vitamin D
/
Vitamin D Deficiency
/
Venous Thrombosis
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
2021
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Basaksehir Cam and Sakura City Hospital/TR
/
Bolu Abant Izzet Baysal University/TR
/
Health Sciences University/TR
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