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Percutaneous injection of ethanol for thyroid nodule treatment: a comparative study
Faculdade de Medicina da BahiaAlcântara-Jones, Daysi Maria de; Borges, Lucas Moura Bastos; Nunes, Tania Freitas A.; Pita, Gabriella Brandão; Rocha, Vinicius Brito; Faculdade de Medicina da BahiaLavinas, Julia Mandaro; Araújo, Leila Maria Batista; Adan, Luis Fernando Fernandes.
  • Faculdade de Medicina da BahiaAlcântara-Jones, Daysi Maria de; Universidade Federal da Bahia. Hospital São Rafael. Faculdade de Medicina da BahiaAlcântara-Jones, Daysi Maria de. Salvador. BR
  • Borges, Lucas Moura Bastos; Universidade Federal da Bahia. Faculdade de Medicina. Salvador. BR
  • Nunes, Tania Freitas A.; Hospital Santo Antonio. Pós-Graduação em Medicina. Salvador. BR
  • Pita, Gabriella Brandão; Universidade Federal da Bahia. Faculdade de Medicina. Salvador. BR
  • Rocha, Vinicius Brito; Universidade Federal da Bahia. Faculdade de Medicina. Salvador. BR
  • Faculdade de Medicina da BahiaLavinas, Julia Mandaro; Universidade Federal da Bahia. Hospital São Rafael. Faculdade de Medicina da BahiaLavinas, Julia Mandaro. Salvador. BR
  • Araújo, Leila Maria Batista; Universidade Federal da Bahia. Faculdade de Medicina. Salvador. BR
  • Adan, Luis Fernando Fernandes; Universidade Federal da Bahia. Faculdade de Medicina. Salvador. BR
Arch. endocrinol. metab. (Online) ; 65(3): 322-327, May-June 2021. tab, graf
Article in English | LILACS | ID: biblio-1285159
ABSTRACT
ABSTRACT

Objective:

Percutaneous ethanol injection (PEI) is an alternative to surgery for the treatment of thyroid nodules (TNs). However, size reductions of treated (TTNs) and untreated TN (UTNs) have not been compared. Volumetric reductions in TTNs with PEI were evaluated by comparing TTNs and UTNs in the same patient, and independent variables predicting good post-PEI outcomes were analyzed. Materials and

methods:

Overall, 282 patients with multinodular goiters were selected. Two nodules located in different lobes were compared for common disease behaviors. Overall, 150 nodules were selected from 75 patients (6 M 69 F) with a mean age of 50.1 ± 17.4 years. This prospective nonrandomized intervention study prioritized treating TNs of greater volume or single hyperfunctioning TNs. A single observer experienced in PEI and an ultrasound specialist performed the interventions. Results and

discussion:

TTNs (mean volume 14.8 ± 16.2 mL) were reduced by 72.6 ± 27.3% of their initial volume, while UTNs increased by a mean of 365.7 ± 1.403.8% (p < 0.00001). The patients underwent a mean of 4.0 ± 3.1 outpatient PEI sessions without relevant complications. Logistic regression analysis showed that the magnitude of the PEI induced reduction was associated with the number of treatment sessions (p = 0.03, CI [1.1-38.2]) and not with ultrasonographic characteristics of the nodules. Each PEI session increased the rate of TN reduction by a factor of 6.7.

Conclusions:

PEI is a well-tolerated outpatient procedure that effectively reduces the volume of TNs and is noticeably superior to conservative treatment for all ultrasonographic classifications.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Thyroid Nodule Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Santo Antonio/BR / Universidade Federal da Bahia/BR

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Full text: Available Index: LILACS (Americas) Main subject: Thyroid Nodule Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Santo Antonio/BR / Universidade Federal da Bahia/BR