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Prevalence of white matter hyperintensities is not elevated in a large sample of adolescents and young adults with bipolar disorder
Mehrhof, Sara Z.; Popel, Najla; Mio, Megan; Lu, Weicong; Division of NeuroradiologyHeyn, Chinthaka C.; Fiksenbaum, Lisa M.; MacIntosh, Bradley J.; Goldstein, Benjamin I..
  • Mehrhof, Sara Z.; Sunnybrook Health Sciences Centre. Centre for Youth Bipolar Disorder. Toronto. CA
  • Popel, Najla; Sunnybrook Health Sciences Centre. Centre for Youth Bipolar Disorder. Toronto. CA
  • Mio, Megan; Sunnybrook Health Sciences Centre. Centre for Youth Bipolar Disorder. Toronto. CA
  • Lu, Weicong; Sunnybrook Health Sciences Centre. Centre for Youth Bipolar Disorder. Toronto. CA
  • Division of NeuroradiologyHeyn, Chinthaka C.; Sunnybrook Health Sciences Centre. Department of Medical Imaging. Division of NeuroradiologyHeyn, Chinthaka C.. Toronto. CA
  • Fiksenbaum, Lisa M.; Sunnybrook Health Sciences Centre. Centre for Youth Bipolar Disorder. Toronto. CA
  • MacIntosh, Bradley J.; University of Toronto Faculty of Medicine. Department of Medical Biophysics. Toronto. CA
  • Goldstein, Benjamin I.; Sunnybrook Health Sciences Centre. Centre for Youth Bipolar Disorder. Toronto. CA
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 43(2): 147-152, Mar.-Apr. 2021. tab
Article in English | LILACS | ID: biblio-1285532
ABSTRACT

Objective:

The increased prevalence rate of white matter hyperintensities is one of the most consistently reported brain abnormalities in adults with bipolar disorder. However, findings in children and adolescents with bipolar disorder are less consistent. Prior studies have been constrained by small sample sizes and/or poor age- and sex-matching of healthy controls. We examined this topic in the largest sample of adolescents with bipolar disorder to date.

Methods:

T2-weighted 3-Tesla magnetic resonance imaging data were acquired for 83 adolescents with bipolar disorder diagnosed via the Kiddie Schedule for Affective Disorders and the Schizophrenia, Present and Lifetime version semi-structured interview and 64 age- and sex-matched healthy controls. All acquired scans were examined by neuroradiologists and the presence or absence of white matter hyperintensities was determined for each participant.

Results:

The prevalence of white matter hyperintensities did not differ between adolescents with bipolar disorder (13.3%) and controls (21.9%; χ2 = 1.90; p = 0.168).

Conclusion:

In contrast to the study hypothesis, the prevalence of white matter hyperintensities was not higher in adolescents with bipolar disorder than controls. The large sample size and good matching for age and sex bolster the reliability of this negative finding. Future studies are warranted to evaluate the prevalence, incidence, and predictors of white matter hyperintensities in early-onset bipolar disorder prospectively.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bipolar Disorder / White Matter Type of study: Prevalence study / Prognostic study / Qualitative research / Risk factors Limits: Adolescent / Child / Humans Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2021 Type: Article Affiliation country: Canada Institution/Affiliation country: Sunnybrook Health Sciences Centre/CA / University of Toronto Faculty of Medicine/CA

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Full text: Available Index: LILACS (Americas) Main subject: Bipolar Disorder / White Matter Type of study: Prevalence study / Prognostic study / Qualitative research / Risk factors Limits: Adolescent / Child / Humans Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2021 Type: Article Affiliation country: Canada Institution/Affiliation country: Sunnybrook Health Sciences Centre/CA / University of Toronto Faculty of Medicine/CA