Prevalence of white matter hyperintensities is not elevated in a large sample of adolescents and young adults with bipolar disorder
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
43(2): 147-152, Mar.-Apr. 2021. tab
Article
in English
| LILACS
| ID: biblio-1285532
ABSTRACT
Objective:
The increased prevalence rate of white matter hyperintensities is one of the most consistently reported brain abnormalities in adults with bipolar disorder. However, findings in children and adolescents with bipolar disorder are less consistent. Prior studies have been constrained by small sample sizes and/or poor age- and sex-matching of healthy controls. We examined this topic in the largest sample of adolescents with bipolar disorder to date.Methods:
T2-weighted 3-Tesla magnetic resonance imaging data were acquired for 83 adolescents with bipolar disorder diagnosed via the Kiddie Schedule for Affective Disorders and the Schizophrenia, Present and Lifetime version semi-structured interview and 64 age- and sex-matched healthy controls. All acquired scans were examined by neuroradiologists and the presence or absence of white matter hyperintensities was determined for each participant.Results:
The prevalence of white matter hyperintensities did not differ between adolescents with bipolar disorder (13.3%) and controls (21.9%; χ2 = 1.90; p = 0.168).Conclusion:
In contrast to the study hypothesis, the prevalence of white matter hyperintensities was not higher in adolescents with bipolar disorder than controls. The large sample size and good matching for age and sex bolster the reliability of this negative finding. Future studies are warranted to evaluate the prevalence, incidence, and predictors of white matter hyperintensities in early-onset bipolar disorder prospectively.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bipolar Disorder
/
White Matter
Type of study:
Prevalence study
/
Prognostic study
/
Qualitative research
/
Risk factors
Limits:
Adolescent
/
Child
/
Humans
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2021
Type:
Article
Affiliation country:
Canada
Institution/Affiliation country:
Sunnybrook Health Sciences Centre/CA
/
University of Toronto Faculty of Medicine/CA
Similar
MEDLINE
...
LILACS
LIS