68Ga-Prostate-specific membrane antigen (PSMA) positron emission tomography (pet) in prostate cancer: a systematic review and meta-analysis
Int. braz. j. urol
;
47(4): 705-729, Jul.-Aug. 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1286767
ABSTRACT
ABSTRACT Introduction:
Prostate cancer (PC) is the second most commonly diagnosed cancer in males. 68Ga-PSMA PET/CT, a non-invasive diagnostic tool to evaluate PC with prostate-specific membrane antigen (PSMA) expression, has emerged as a more accurate alternative to assess disease staging. We aimed to identify predictors of positive 68Ga-PSMA PET and the accuracy of this technique. Materials andmethods:
Diagnostic accuracy cross-sectional study with prospective and retrospective approaches. We performed a comprehensive literature search on PubMed, Cochrane Library, and Embase database in search of studies including PC patients submitted to radical prostatectomy or radiotherapy with curative intent and presented biochemical recurrence following ASTRO 1996 criteria. A total of 35 studies involving 3910 patients submitted to 68-Ga-PSMA PET were included and independently assessed by two authors 8 studies on diagnosis, four on staging, and 23 studies on restaging purposes. The significance level was α=0.05.Results:
pooled sensitivity and specificity were 0.90 (0.86-0.93) and 0.90 (0.82-0.96), respectively, for diagnostic purposes; as for staging, pooled sensitivity and specificity were 0.93 (0.86-0.98) and 0.96 (0.92-0.99), respectively. In the restaging scenario, pooled sensitivity and specificity were 0.76 (0.74-0.78) and 0.45 (0.27-0.58), respectively, considering the identification of prostate cancer in each described situation. We also obtained specificity and sensitivity results for PSA subdivisions.Conclusion:
68Ga-PSMA PET provides higher sensitivity and specificity than traditional imaging for prostate cancer.
Full text:
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Index:
LILACS (Americas)
Main subject:
Prostatic Neoplasms
/
Positron Emission Tomography Computed Tomography
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Humans
/
Male
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2021
Type:
Article
Affiliation country:
Brazil
/
Italy
Institution/Affiliation country:
Clínica Kozma/BR
/
Instituto Hospital Erasto Gaertner/BR
/
Instituto do Câncer de São Paulo/BR
/
Núcleos Centro de Medicina Nuclear/BR
/
OncoPETscan/BR
/
Pontifícia Universidade Católica do Rio Grande do Sul/BR
/
Quanta Diagnóstico e Terapia/BR
/
Real Hospital Português de Beneficência/BR
/
USP/BR
/
Universidade Estadual de Campinas/BR
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