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68Ga-Prostate-specific membrane antigen (PSMA) positron emission tomography (pet) in prostate cancer: a systematic review and meta-analysis
Matushita, Cristina S; Silva, Ana M Marques da; Schuck, Phelipi N; Bardisserotto, Matteo; Piant, Diego B; Pereira, Jonatas L; Cerci, Juliano J; Coura Filho, George B; Esteves, Fabio P; Amorim, Barbara J; Gomes, Gustavo V; Brito, Ana Emília T; Bernardo, Wanderley M; Mundstock, Eduardo; Fanti, Stefano; Macedo, Bruna; Roman, Diego H; Tem-Pass, Cinthia Scatolin; Hochhegger, Bruno.
  • Matushita, Cristina S; Pontifícia Universidade Católica do Rio Grande do Sul. Instituto do Cérebro do Rio Grande do Sul. Porto Alegre. BR
  • Silva, Ana M Marques da; Pontifícia Universidade Católica do Rio Grande do Sul. Instituto do Cérebro do Rio Grande do Sul. Porto Alegre. BR
  • Schuck, Phelipi N; Pontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Ciências. Laboratório de Imagens Médicas. Porto Alegre. BR
  • Bardisserotto, Matteo; Clínica Kozma. Balneário Camboriú. BR
  • Piant, Diego B; Pontifícia Universidade Católica do Rio Grande do Sul. Instituto do Cérebro do Rio Grande do Sul. Porto Alegre. BR
  • Pereira, Jonatas L; Instituto Hospital Erasto Gaertner. Curitiba. BR
  • Cerci, Juliano J; Quanta Diagnóstico e Terapia. Curitiba. BR
  • Coura Filho, George B; Instituto do Câncer de São Paulo. Departamento de Medicina Nuclear. São Paulo. BR
  • Esteves, Fabio P; OncoPETscan. Blumenau. BR
  • Amorim, Barbara J; Universidade Estadual de Campinas. Departamento de Medicina Nuclear. Campinas. BR
  • Gomes, Gustavo V; Núcleos Centro de Medicina Nuclear. Guará. BR
  • Brito, Ana Emília T; Real Hospital Português de Beneficência. Pernambuco. BR
  • Bernardo, Wanderley M; USP. Faculdade de Medicina. Programa de Pós-Graduação em Medicina. São Paulo. BR
  • Mundstock, Eduardo; Pontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Saúde da Criança. Porto Alegre. BR
  • Fanti, Stefano; University of Bologna. Diagnostic and Specialized Medicine. Department of Experimental. Bologna. IT
  • Macedo, Bruna; Pontifícia Universidade Católica do Rio Grande do Sul. Instituto do Cérebro do Rio Grande do Sul. Porto Alegre. BR
  • Roman, Diego H; Pontifícia Universidade Católica do Rio Grande do Sul. Instituto do Cérebro do Rio Grande do Sul. Porto Alegre. BR
  • Tem-Pass, Cinthia Scatolin; Pontifícia Universidade Católica do Rio Grande do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Saúde da Criança. Porto Alegre. BR
  • Hochhegger, Bruno; Pontifícia Universidade Católica do Rio Grande do Sul. Instituto do Cérebro do Rio Grande do Sul. Porto Alegre. BR
Int. braz. j. urol ; 47(4): 705-729, Jul.-Aug. 2021. tab, graf
Article in English | LILACS | ID: biblio-1286767
ABSTRACT
ABSTRACT

Introduction:

Prostate cancer (PC) is the second most commonly diagnosed cancer in males. 68Ga-PSMA PET/CT, a non-invasive diagnostic tool to evaluate PC with prostate-specific membrane antigen (PSMA) expression, has emerged as a more accurate alternative to assess disease staging. We aimed to identify predictors of positive 68Ga-PSMA PET and the accuracy of this technique. Materials and

methods:

Diagnostic accuracy cross-sectional study with prospective and retrospective approaches. We performed a comprehensive literature search on PubMed, Cochrane Library, and Embase database in search of studies including PC patients submitted to radical prostatectomy or radiotherapy with curative intent and presented biochemical recurrence following ASTRO 1996 criteria. A total of 35 studies involving 3910 patients submitted to 68-Ga-PSMA PET were included and independently assessed by two authors 8 studies on diagnosis, four on staging, and 23 studies on restaging purposes. The significance level was α=0.05.

Results:

pooled sensitivity and specificity were 0.90 (0.86-0.93) and 0.90 (0.82-0.96), respectively, for diagnostic purposes; as for staging, pooled sensitivity and specificity were 0.93 (0.86-0.98) and 0.96 (0.92-0.99), respectively. In the restaging scenario, pooled sensitivity and specificity were 0.76 (0.74-0.78) and 0.45 (0.27-0.58), respectively, considering the identification of prostate cancer in each described situation. We also obtained specificity and sensitivity results for PSA subdivisions.

Conclusion:

68Ga-PSMA PET provides higher sensitivity and specificity than traditional imaging for prostate cancer.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Prostatic Neoplasms / Positron Emission Tomography Computed Tomography Type of study: Observational study / Prevalence study / Prognostic study / Risk factors / Systematic reviews Limits: Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: Brazil / Italy Institution/Affiliation country: Clínica Kozma/BR / Instituto Hospital Erasto Gaertner/BR / Instituto do Câncer de São Paulo/BR / Núcleos Centro de Medicina Nuclear/BR / OncoPETscan/BR / Pontifícia Universidade Católica do Rio Grande do Sul/BR / Quanta Diagnóstico e Terapia/BR / Real Hospital Português de Beneficência/BR / USP/BR / Universidade Estadual de Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Prostatic Neoplasms / Positron Emission Tomography Computed Tomography Type of study: Observational study / Prevalence study / Prognostic study / Risk factors / Systematic reviews Limits: Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: Brazil / Italy Institution/Affiliation country: Clínica Kozma/BR / Instituto Hospital Erasto Gaertner/BR / Instituto do Câncer de São Paulo/BR / Núcleos Centro de Medicina Nuclear/BR / OncoPETscan/BR / Pontifícia Universidade Católica do Rio Grande do Sul/BR / Quanta Diagnóstico e Terapia/BR / Real Hospital Português de Beneficência/BR / USP/BR / Universidade Estadual de Campinas/BR