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Quercetin as a nephroprotector after warm ischemia: histomorphometric evaluation in a rodent model
Gonçalves, Gabriela F Buys; Silva, Maria Eduarda M; Sampaio, Francisco J B; Pereira-Sampaio, Marco A; Souza, Diogo Benchimol de.
  • Gonçalves, Gabriela F Buys; Universidade do Estado do Rio de Janeiro - UERJ. Unidade de Pesquisa Urogenital. Rio de Janeiro. BR
  • Silva, Maria Eduarda M; Fundação Educacional Serra dos Órgãos. Departamento de Medicina Veterinária. Teresópolis. BR
  • Sampaio, Francisco J B; Universidade do Estado do Rio de Janeiro - UERJ. Unidade de Pesquisa Urogenital. Rio de Janeiro. BR
  • Pereira-Sampaio, Marco A; Universidade do Estado do Rio de Janeiro - UERJ. Unidade de Pesquisa Urogenital. Rio de Janeiro. BR
  • Souza, Diogo Benchimol de; Universidade do Estado do Rio de Janeiro - UERJ. Unidade de Pesquisa Urogenital. Rio de Janeiro. BR
Int. braz. j. urol ; 47(4): 796-802, Jul.-Aug. 2021. tab, graf
Article in English | LILACS | ID: biblio-1286776
ABSTRACT
ABSTRACT

Purpose:

To quantitatively evaluate the possible long-term protective effects of quercetin during renal warm ischemia. Materials and

Methods:

Male rats were allocated into 4 groups sham (S), sham quercetin (SQ), ischemia (I), and ischemia quercetin (IQ). Groups SQ and IQ received quercetin (50mg/kg) before and after surgery. Groups I and IQ had their left renal vessels clamped for 60 minutes. All animals were euthanized four weeks after the procedure, and serum urea and creatinine levels were measured. Renal weight and volume, cortex-non-cortex area ratio (C-NC), cortical volume (CV), glomerular volumetric density (Vv[glom]), volume-weighted glomerular volume (VWGV) and number of glomeruli per kidney (N[glom]) were evaluated by stereological methods. Results were considered statistically significant when p <0.05.

Results:

Serum urea levels in group I increased by 10.4% in relation to group S, but no differences were observed among the other groups. The C-NC of group I was lower than those of all other groups, and group IQ had similar results to sham groups. The Vv[glom] and N[glom] of group I were lower than those of group S (33.7% and 28.3%, respectively) and group IQ had no significant difference compared to the S group.

Conclusions:

Quercetin was effective as a nephroprotective agent in preventing the glomerular loss observed when the kidney was subjected to warm ischemia. This suggests that this flavonoid may be used preventively in kidney surgery, when warm ischemia is necessary, such as partial nephrectomy.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Quercetin / Warm Ischemia Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Educacional Serra dos Órgãos/BR / Universidade do Estado do Rio de Janeiro - UERJ/BR

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Full text: Available Index: LILACS (Americas) Main subject: Quercetin / Warm Ischemia Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Educacional Serra dos Órgãos/BR / Universidade do Estado do Rio de Janeiro - UERJ/BR