Your browser doesn't support javascript.
loading
Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
Sarno, Alice; Daltro, Cleidiane Borges; Mendes, Carlos Mauricio Cardeal; Barbosa, Theolis.
  • Sarno, Alice; Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador. BR
  • Daltro, Cleidiane Borges; Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador. BR
  • Mendes, Carlos Mauricio Cardeal; Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador. BR
  • Barbosa, Theolis; Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador. BR
Rev. Soc. Bras. Med. Trop ; 54: e00172021, 2021. tab, graf
Article in English | LILACS | ID: biblio-1288068
ABSTRACT
Abstract

INTRODUCTION:

Tuberculosis (TB) is the leading cause of death worldwide caused by a single infectious disease agent. Brazil, Russia, India, China, and South Africa (BRICS) account for more than half of the world's TB cases. Bacillus Calmette-Guérin (BCG) remains the only vaccine available despite its variable efficacy. Promising antigen-based vaccines have been proposed as prophylactic and/or immunotherapeutic approaches to boost BCG vaccination. Relevant antigens must interact with the range of human leukocyte antigen (HLA) molecules present in target populations; yet this information is currently not available.

METHODS:

MEDLINE and EMBASE were systematically searched for articles published during 2013-2020 to measure the allelic frequencies of HLA-DRB1 in the BRICS.

RESULTS:

In total, 67 articles involving 3,207,861 healthy individuals were included in the meta-analysis. HLA-DRB1 alleles *03, *04, *07, *11, *13, and *15 were consistently identified at high frequencies across the BRICS, with a combined estimated frequency varying from 52% to 80%. HLA-DRB1 alleles *01, *08, *09, *10, *12, and *14 were found to be relevant in only one or two BRICS populations.

CONCLUSIONS:

By combining these alleles, it is possible to ensure at least 80% coverage throughout the BRICS populations.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tuberculosis Type of study: Prognostic study / Systematic reviews Limits: Humans Country/Region as subject: Africa / South America / Asia / Brazil / Europa Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Universidade Federal da Bahia/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Tuberculosis Type of study: Prognostic study / Systematic reviews Limits: Humans Country/Region as subject: Africa / South America / Asia / Brazil / Europa Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Universidade Federal da Bahia/BR