Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis
Rev. Soc. Bras. Med. Trop
;
54: e00172021, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1288068
ABSTRACT
Abstract INTRODUCTION:
Tuberculosis (TB) is the leading cause of death worldwide caused by a single infectious disease agent. Brazil, Russia, India, China, and South Africa (BRICS) account for more than half of the world's TB cases. Bacillus Calmette-Guérin (BCG) remains the only vaccine available despite its variable efficacy. Promising antigen-based vaccines have been proposed as prophylactic and/or immunotherapeutic approaches to boost BCG vaccination. Relevant antigens must interact with the range of human leukocyte antigen (HLA) molecules present in target populations; yet this information is currently not available.METHODS:
MEDLINE and EMBASE were systematically searched for articles published during 2013-2020 to measure the allelic frequencies of HLA-DRB1 in the BRICS.RESULTS:
In total, 67 articles involving 3,207,861 healthy individuals were included in the meta-analysis. HLA-DRB1 alleles *03, *04, *07, *11, *13, and *15 were consistently identified at high frequencies across the BRICS, with a combined estimated frequency varying from 52% to 80%. HLA-DRB1 alleles *01, *08, *09, *10, *12, and *14 were found to be relevant in only one or two BRICS populations.CONCLUSIONS:
By combining these alleles, it is possible to ensure at least 80% coverage throughout the BRICS populations.
Full text:
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Index:
LILACS (Americas)
Main subject:
Tuberculosis
Type of study:
Prognostic study
/
Systematic reviews
Limits:
Humans
Country/Region as subject:
Africa
/
South America
/
Asia
/
Brazil
/
Europa
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
/
Universidade Federal da Bahia/BR
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