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The Impact of Transcatheter Aortic Valve Implantation (TAVI) on Serum Apelin Levels in Patients with Aortic Valvular Stenosis
Kucukosmanoglu, Mehmet; Sahin, Seyda; Urgun, Orsan Deniz; Yildirim, Arafat; Kilic, Salih; Sen, Omer; Kurt, Ibrahim Halil.
  • Kucukosmanoglu, Mehmet; Health Sciences University. Adana Training and Research Hospital. Department of Cardiology. Adana. TR
  • Sahin, Seyda; Health Sciences University. Adana Training and Research Hospital. Department of Cardiology. Adana. TR
  • Urgun, Orsan Deniz; Health Sciences University. Adana Training and Research Hospital. Department of Cardiology. Adana. TR
  • Yildirim, Arafat; Health Sciences University. Adana Training and Research Hospital. Department of Cardiology. Adana. TR
  • Kilic, Salih; Health Sciences University. Adana Training and Research Hospital. Department of Cardiology. Adana. TR
  • Sen, Omer; Health Sciences University. Adana Training and Research Hospital. Department of Cardiology. Adana. TR
  • Kurt, Ibrahim Halil; Health Sciences University. Adana Training and Research Hospital. Department of Cardiology. Adana. TR
Rev. bras. cir. cardiovasc ; 36(3): 372-378, May-June 2021. tab, graf
Article in English | LILACS | ID: biblio-1288249
ABSTRACT
Abstract

Introduction:

In this study, we aimed to investigate the impact of transcatheter aortic valve implantation (TAVI) on serum apelin levels in patients with severe symptomatic aortic valve stenosis (AS).

Methods:

Forty-six consecutive patients (76.9±7.4 years, n=27 women) who underwent TAVI and 45 age- and sex-matched control subjects were included in the study. Echocardiographic parameters, serum apelin, pro-brain natriuretic peptide (Pro-BNP), and troponin I levels were compared between the groups. In addition, the preprocedural and first-month follow-up echocardiographic parameters and serum apelin values of TAVI patients were compared.

Results:

Serum median troponin I and Pro-BNP levels were significantly higher and serum apelin levels were significantly lower in TAVI patients before TAVI procedure than in the control subjects (P<0.001, for all). Median troponin I and Pro-BNP levels were significantly decreased and apelin levels were significantly increased after TAVI procedure compared to the peri-procedural levels. There was a significant and moderate negative correlation between Pro-BNP and apelin levels measured before and after TAVI procedure. A statistically significant and strong negative correlation was found between aortic valve area and Pro-BNP level before TAVI procedure, while a statistically significant but weak positive correlation was found between valve area and apelin level.

Conclusion:

In our study, apelin levels were significantly lower and Pro-BNP levels were higher in AS patients compared with the control group. Moreover, after TAVI procedure, a significant increase in apelin levels and a significant decrease in Pro-BNP levels were observed. There was also a negative and moderate correlation between apelin and Pro-BNP levels.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Aortic Valve Stenosis / Transcatheter Aortic Valve Replacement Limits: Female / Humans Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Health Sciences University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Aortic Valve Stenosis / Transcatheter Aortic Valve Replacement Limits: Female / Humans Language: English Journal: Rev. bras. cir. cardiovasc Journal subject: Cardiology / General Surgery Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Health Sciences University/TR