Small airway disease in COPD associated to biomass exposure
Rev. invest. clín
; 71(1): 70-78, Jan.-Feb. 2019. tab, graf
Article
in En
| LILACS
| ID: biblio-1289671
Responsible library:
BR1.1
ABSTRACT
Abstract Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous entity that may result from different causative agents and risk factors and may follow diverse clinical courses, including COPD secondary to biomass smoke exposure. At present, this phenotype is becoming more important for two reasons first, because at least almost half of the worlds population is exposed to biomass smoke, and second, because the possibility of it being diagnosed is increasing. Biomass smoke exposure COPD affects primarily women and is related with insults to the airways occurred during early life. Although constituents of biomass smoke and tobacco smoke are similar, the physiopathological changes they induce differ depending not only on the chemical composition (related with the type of fuel used) but also on the particle size and the inhalation pattern. Evidence has shown that biomass smoke exposure affects the airway, predominantly the small airways causing anthracofibrosis and peribronchiolar fibrosis changes that will clinically translate into chronic bronchitis symptoms, with a high impact on the quality of life. In this review, we focus especially on the main epidemiological and clinical differences between COPD secondary to biomass exposure and COPD caused by tobacco exposure.
Key words
Full text:
1
Index:
LILACS
Main subject:
Smoke
/
Biomass
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Rev. invest. clín
Journal subject:
MEDICINA
Year:
2019
Type:
Article