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Association of blood heavy metal levels with osteocalcin abnormality and incidence of osteoporosis in Saudi subjects / Associação de anormalidades de osteocalcina nos níveis de metais pesados no sangue e incidência de osteoporose em indivíduos sauditas
Banjabi, A A; Kannan, K; Kumosani, T A; Yousef, J M; Abulnaja, K O; Moselhy, S S.
  • Banjabi, A A; King Abdulaziz University. Faculty of Science. Biochemistry Department. Jeddah. SA
  • Kannan, K; University School of Medicine. Department of Environmental Medicine. US
  • Kumosani, T A; King Abdulaziz University. Faculty of Science. Biochemistry Department. Jeddah. SA
  • Yousef, J M; University of Jeddah. College of Science, Department of Biochemistry. Jeddah. SA
  • Abulnaja, K O; King Abdulaziz University. Faculty of Science. Biochemistry Department. Jeddah. SA
  • Moselhy, S S; Ain Shams University. Faculty of Science. Biochemistry Department. Cairo. EG
Braz. j. biol ; 83: e248828, 2023. tab
Article in English | LILACS, VETINDEX | ID: biblio-1339354
ABSTRACT
Abstract Serum toxic metals have been implicated in development of many diseases. This study investigated the association between blood levels of lead and cadmium with abnormal bone mineral density (BMD) and incidence of osteoporosis. Sixty Saudi male adults age matching were assigned into two groups A healthy control group (n = 30) and osteoporosis patients diagnosed according to T-score (n = 30). Serum calcium, vitamin D, osteocalcin, lead, cadmium were measured. Osteoporotic group showed a highly significant elevation of blood lead and cadmium levels compared to the control group (p <0.001). BMD was negatively correlated with serum osteocalcin level compared with control. There was a significant negative correlation between the cadmium and lead levels (r=-0.465 and p-value = 0.01) and calcium (p < 0.004). Our findings suggested that high cadmium and lead were negative correlated to BMD and increased the risk factor for osteoporosis.
RESUMO
Resumo Os metais tóxicos do soro têm sido implicados no desenvolvimento de muitas doenças. Este estudo investigou a associação entre os níveis sanguíneos de chumbo e cádmio com densidade mineral óssea anormal (DMO) e incidência de osteoporose. Sessenta adultos sauditas do sexo masculino com idades iguais foram divididos em dois grupos um grupo de controle saudável (n = 30) e pacientes com osteoporose diagnosticados de acordo com o T-score (n = 30). Cálcio sérico, vitamina D, osteocalcina, chumbo, cádmio foram medidos. O grupo osteoporótico apresentou elevação altamente significativa dos níveis de chumbo e cádmio no sangue em comparação ao grupo controle (p < 0,001). A DMO foi negativamente correlacionada com o nível de osteocalcina sérica em comparação com o controle. Houve correlação negativa significativa entre os níveis de cádmio e chumbo (r = -0,465 ep = 0,01) e cálcio (p < 0,004). Nossos achados sugeriram que cádmio e chumbo elevados foram correlacionados negativamente à DMO e aumentaram o fator de risco para osteoporose.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Osteoporosis / Lead Type of study: Incidence study / Prognostic study / Risk factors / Screening study Limits: Adult / Humans / Male Country/Region as subject: Asia Language: English Journal: Braz. j. biol Year: 2023 Type: Article Institution/Affiliation country: Ain Shams University/EG / King Abdulaziz University/SA / University School of Medicine/US / University of Jeddah/SA

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Full text: Available Index: LILACS (Americas) Main subject: Osteoporosis / Lead Type of study: Incidence study / Prognostic study / Risk factors / Screening study Limits: Adult / Humans / Male Country/Region as subject: Asia Language: English Journal: Braz. j. biol Year: 2023 Type: Article Institution/Affiliation country: Ain Shams University/EG / King Abdulaziz University/SA / University School of Medicine/US / University of Jeddah/SA