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Diagnostic value of heparin-binding protein in the cerebrospinal fluid for purulent meningitis in children
Ren, Dan; Wu, Di; Liu, Fu; Jiao, Shuli; Wu, Yi.
  • Ren, Dan; Mianyang Central Hospital. Department of Pediatrics. Mianyang. CN
  • Wu, Di; Hospital of PLA Unit 63820. Department of Gynecology and Pediatrics. Mianyang. CN
  • Liu, Fu; Mianyang Central Hospital. Department of Pediatrics. Mianyang. CN
  • Jiao, Shuli; Mianyang Central Hospital. Department of Pediatrics. Mianyang. CN
  • Wu, Yi; Mianyang Central Hospital. Department of Pediatrics. Mianyang. CN
Braz. j. med. biol. res ; 54(11): e11295, 2021. tab, graf
Article in English | LILACS | ID: biblio-1339451
ABSTRACT
This study aimed to investigate the diagnostic value of heparin-binding protein (HBP) in the cerebrospinal fluid of children with purulent meningitis (PM). This study included 118 children with PM diagnosed at our hospital from January 2018 to January 2020, 110 children with viral meningitis (VM) and 80 children with suspected meningitis who were ruled out by cerebrospinal fluid (CSF) analysis during the same period. HBP and white blood cell (WBC) count in the CSF, and inflammatory factors, including C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and procalcitonin (PCT), were measured. Receiver-operator characteristic curves were used to analyze the predictive value of HBP, CRP, PCT, and TNF-α levels in the diagnosis of PM by CSF analysis. HBP levels in the CSF of children with PM were higher, while the CRP and serum PCT and TNF-α levels were elevated in all groups (P<0.05). In addition, HBP levels in the CSF were more accurate for the diagnosis of PM than traditional diagnostic indexes. HBP levels in the CSF can be used as an important reference for early diagnosis of PM.
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Full text: Available Index: LILACS (Americas) Main subject: Meningitis, Bacterial / Meningitis, Viral Type of study: Diagnostic study / Prognostic study / Screening study Limits: Child / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Hospital of PLA Unit 63820/CN / Mianyang Central Hospital/CN

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Full text: Available Index: LILACS (Americas) Main subject: Meningitis, Bacterial / Meningitis, Viral Type of study: Diagnostic study / Prognostic study / Screening study Limits: Child / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Hospital of PLA Unit 63820/CN / Mianyang Central Hospital/CN