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Effectiveness of different methods for the extraction of principle actives and phytochemicals content in medicinal herbals / Efectividad de diferentes métodos para la extracción de principios activos y contenido de fitoquímicos en hierbas medicinales
Lima, Nerilson M; Falcoski, Thais O; Silveira, Romena S; Vieira, Haustin S; Santos, Vanessa N. C; Ramos, Rhianne R; Silva, Júlio Cesar De P; Andrade, Teresinha de Jesus A. Dos S; Carli, Alessandra e P; Costa, Paulo I; La Porta, Felipe A; Almeida, Mauro V.
  • Lima, Nerilson M; Federal University of the Jequitinhonha and Mucuri Valleys. Institute of Science. BR
  • Falcoski, Thais O; Paulista State University "Júlio de Mesquita Filho". Pharmacy College. BR
  • Silveira, Romena S; Federal University of the Jequitinhonha and Mucuri Valleys. Institute of Science. BR
  • Vieira, Haustin S; Federal Technological University of Paraná. Nanotechnology and Computational Chemistry Laboratory-Nano QC. BR
  • Santos, Vanessa N. C; Federal University of Amazonas. Biotechnology Department. Institute of Biological Science (ICB). Manaos. BR
  • Ramos, Rhianne R; Federal University of the Jequitinhonha and Mucuri Valleys. Institute of Science. BR
  • Silva, Júlio Cesar De P; Paulista State University "Júlio de Mesquita Filho". Pharmacy College. BR
  • Andrade, Teresinha de Jesus A. Dos S; Science and Technology of Maranhão. Federal Institute of Education. Research Center Applied to the Science (NIAC). São Luis. BR
  • Carli, Alessandra e P; Federal University of the Jequitinhonha and Mucuri Valleys. Institute of Science. BR
  • Costa, Paulo I; Paulista State University "Júlio de Mesquita Filho". Pharmacy College. BR
  • La Porta, Felipe A; Federal Technological University of Paraná. Nanotechnology and Computational Chemistry Laboratory-Nano QC. BR
  • Almeida, Mauro V; Federal University of Juiz de Fora. Organic Chemistry Department. BR
Bol. latinoam. Caribe plantas med. aromát ; 20(3): 324-338, may. 2021. tab, ilus
Article in English | LILACS | ID: biblio-1343496
ABSTRACT
In this present study, we investigated the influence of various extraction methods including maceration, sonication, infusion, decoction, and microwave extraction, on the chemical and biological potential of phytochemicals extracted from three medicinal plants (Ageratum conyzoides, Plantago majorand Arctium lappa L). The results were subsequently analyzed by variance analysis. Our results suggested that sonication is the most effective extraction method among the five methods tested herein, for the extraction of phytochemicals that have a high antioxidant potential and high phenolic content. The three plants employed for this study had a high concentration of flavonoids and phenolics which was compatible with the chemosystematics of the species. All the samples possessed a Sun Protection Factor (SPF) of less than 6. Interestingly, a maximum reaction time of approximately 20 min was noted for the complexation of AlCl3 with the flavonoids present in the phytochemical extract during analyses of the kinetic parameters. We finally identified that the Ageratum conyzoides extract, prepared by sonication, possessed a significant pharmacological potential against hepatocarcinoma tumour cells, whose result can guide further studies for its therapeutic efficacy.
RESUMEN
En el presente estudio, investigamos la influencia de varios métodos de extracción, incluyendo maceración, sonicación, infusión, decocción y extracción por microondas, sobre el potencial químico y biológico de los fitoquímicos extraídos de tres plantas medicinales (Ageratum conyzoides, Plantago majory Arctium lappa L). Los resultados se analizaron posteriormente mediante análisis de varianza. Nuestros resultados sugieren que la sonicación es el método de extracción más eficaz entre los cinco métodos aquí probados, para la extracción de fitoquímicos que tienen un alto potencial antioxidante y un alto contenido fenólico. Las tres plantas empleadas para este estudio tenían una alta concentración de flavonoides y fenólicos que era compatible con la quimiosistemática de las especies. Todas las muestras poseían un factor de protección solar (SPF) menor a 6. Curiosamente, se observó un tiempo máximo de reacción de aproximadamente 20 min para la complejación de AlCl3con los flavonoides presentes en el extracto fitoquímico durante los análisis de los parámetros cinéticos. Finalmente, identificamos que el extracto de Ageratum conyzoides, elaborado por sonicación, posee un importante potencial farmacológico frente a las células tumorales del hepatocarcinoma, cuyo resultado puede orientar nuevos estudios sobre su eficacia terapéutica.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Plants, Medicinal / Phytochemicals Type of study: Prognostic study Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal Technological University of Paraná/BR / Federal University of Amazonas/BR / Federal University of Juiz de Fora/BR / Federal University of the Jequitinhonha and Mucuri Valleys/BR / Paulista State University "Júlio de Mesquita Filho"/BR / Science and Technology of Maranhão/BR

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Full text: Available Index: LILACS (Americas) Main subject: Plants, Medicinal / Phytochemicals Type of study: Prognostic study Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal Technological University of Paraná/BR / Federal University of Amazonas/BR / Federal University of Juiz de Fora/BR / Federal University of the Jequitinhonha and Mucuri Valleys/BR / Paulista State University "Júlio de Mesquita Filho"/BR / Science and Technology of Maranhão/BR