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Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
Eyerer, Frederick; Gardner, Juli-Anne; Devitt, Katherine A.
  • Eyerer, Frederick; University of Vermont Medical Center. Department of Pathology and Laboratory Medicine. Burlington. US
  • Gardner, Juli-Anne; University of Vermont Medical Center. Department of Pathology and Laboratory Medicine. Burlington. US
  • Devitt, Katherine A; University of Vermont Medical Center. Department of Pathology and Laboratory Medicine. Burlington. US
Autops. Case Rep ; 11: e2021340, 2021. graf
Article in English | LILACS | ID: biblio-1345359
ABSTRACT
Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.
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Full text: Available Index: LILACS (Americas) Main subject: Splenic Rupture / Lymphoma, Mantle-Cell Limits: Aged / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: United States Institution/Affiliation country: University of Vermont Medical Center/US

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Full text: Available Index: LILACS (Americas) Main subject: Splenic Rupture / Lymphoma, Mantle-Cell Limits: Aged / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: United States Institution/Affiliation country: University of Vermont Medical Center/US