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Minimal residual disease assessment in acute lymphoblastic leukemia by 4-color flow cytometry: Recommendations from the MRD Working Group of the Brazilian Society of Bone Marrow Transplantation
Ikoma-Colturato, Maura R. V; Beltrame, Miriam P; Furtado, Felipe M; Pimenta, Glicinia; Costa, Elaine Sobral da; Azambuja, Ana Paula; Malvezzi, Mariester; Yamamoto, Mihoko.
  • Ikoma-Colturato, Maura R. V; Hospital Amaral Carvalho. Jaú. BR
  • Beltrame, Miriam P; Hospital Erasto Gaertner. Curitiba. BR
  • Furtado, Felipe M; Sabin Medicina Diagnóstica. Brasília. BR
  • Pimenta, Glicinia; Universidade Federal do Rio de Janeiro - UFRJ. Rio de Janeiro. BR
  • Costa, Elaine Sobral da; Universidade Federal do Rio de Janeiro - UFRJ. Rio de Janeiro. BR
  • Azambuja, Ana Paula; Universidade Federal do Paraná - UFPR. Hospital de Clínicas. Curitiba. BR
  • Malvezzi, Mariester; Universidade Federal do Paraná - UFPR. Hospital de Clínicas. Curitiba. BR
  • Yamamoto, Mihoko; Universidade Federal de São Paulo - UNIFESP. São Paulo. BR
Hematol., Transfus. Cell Ther. (Impr.) ; 43(3): 332-340, July-Sept. 2021. tab, graf
Article in English | LILACS | ID: biblio-1346264
ABSTRACT
Abstract

Introduction:

The minimal residual disease (MRD) status plays a crucial role in the treatment of acute lymphoblastic leukemia (ALL) and is currently used in most therapeutic protocols to guide the appropriate therapeutic decision. Therefore, it is imperative that laboratories offer accurate and reliable results through well standardized technical processes by establishing rigorous operating procedures.

Method:

Our goal is to propose a monoclonal antibody (MoAb) panel for MRD detection in ALL and provide recommendations intended for flow cytometry laboratories that work on 4-color flow cytometry platforms. Results and

conclusion:

The document includes pre-analytical and analytical procedures, quality control assurance, technical procedures, as well as the information that needs to be included in the reports for clinicians.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Neoplasm, Residual / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Flow Cytometry Type of study: Practice guideline / Prognostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Hematol., Transfus. Cell Ther. (Impr.) Journal subject: Hematologia / TransfusÆo de Sangue Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Amaral Carvalho/BR / Hospital Erasto Gaertner/BR / Sabin Medicina Diagnóstica/BR / Universidade Federal de São Paulo - UNIFESP/BR / Universidade Federal do Paraná - UFPR/BR / Universidade Federal do Rio de Janeiro - UFRJ/BR

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Full text: Available Index: LILACS (Americas) Main subject: Neoplasm, Residual / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Flow Cytometry Type of study: Practice guideline / Prognostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Hematol., Transfus. Cell Ther. (Impr.) Journal subject: Hematologia / TransfusÆo de Sangue Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Amaral Carvalho/BR / Hospital Erasto Gaertner/BR / Sabin Medicina Diagnóstica/BR / Universidade Federal de São Paulo - UNIFESP/BR / Universidade Federal do Paraná - UFPR/BR / Universidade Federal do Rio de Janeiro - UFRJ/BR