Coronavirus persistence in human respiratory tract and cell culture: An overview
Braz. j. infect. dis
;
25(5): 101632, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1350317
ABSTRACT
ABSTRACT Emerging human coronaviruses, including the recently identified SARS-CoV-2, are relevant respiratory pathogens due to their potential to cause epidemics with high case fatality rates, although endemic coronaviruses are also important for immunocompromised patients. Long-term coronavirus infections had been described mainly in experimental models, but it is currently evident that SARS-CoV-2 genomic-RNA can persist for many weeks in the respiratory tract of some individuals clinically recovered from coronavirus infectious disease-19 (COVID-19), despite a lack of isolation of infectious virus. It is still not clear whether persistence of such viral RNA may be pathogenic for the host and related to long-term sequelae. In this review, we summarize evidence of SARS-CoV-2 RNA persistence in respiratory samples besides results obtained from cell culture and histopathology describing long-term coronavirus infection. We also comment on potential mechanisms of coronavirus persistence and relevance for pathogenesis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
RNA, Viral
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2021
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Universidad Nacional Autonoma de Mexico/MX
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