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Immunogenicity after CoronaVac vaccination
Güzel, Eda Çelik; Çelikkol, Aliye; Erdal, Berna; Sedef, Nuriye.
  • Güzel, Eda Çelik; Tekirdag˘ Namik Kemal University. Faculty of Medicine. Department of Family Physician. Tekirdag. TR
  • Çelikkol, Aliye; Tekirdag˘ Namik Kemal University. Faculty of Medicine. Department of Medical Biochemistry. Tekirdag. TR
  • Erdal, Berna; Tekirdag˘ Namik Kemal University. Faculty of Medicine. Department of Medical Microbiology. Tekirdag. TR
  • Sedef, Nuriye; Tekirdag˘ Namik Kemal University. Faculty of Medicine. Department of Family Physician. Tekirdag. TR
Rev. Assoc. Med. Bras. (1992) ; 67(10): 1403-1408, Oct. 2021. tab, graf
Article in English | LILACS | ID: biblio-1351446
ABSTRACT
SUMMARY

OBJECTIVE:

This study aimed to investigate the seropositivity of CoronaVac-SinoVac vaccination in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) risk factors and comorbidities.

METHODS:

Immunoglobulin (IgG) antibody responses were examined on the 21st day after the second dose of CoronaVac-SinoVac 6 μg vaccine on the 28th day. SARS-CoV-2 IgG antibody levels were measured by using the enzyme-linked immunosorbent assay method in vaccinated health care workers (n=134) (Group I), vaccinated polymerase chain reaction (PCR) (+) who had coronavirus-19 (COVID-19) disease (n=21) (Group II), and unvaccinated PCR (+) (n=28) (Group III) participants. Subgroups were formed in Group I according to the presence of COVID-19 risk factors and comorbidities (diabetes mellitus, cardiovascular disease, and asthma/allergy) and demographic data.

RESULTS:

Seropositivity rates were 95.5, 100, and 89.3% for Groups I, II, and III, respectively. IgG antibody levels were found significantly higher in the group between the ages of 20-30 in group I compared to those aged 31-50 and over 50 (both p<0.01). It was found significantly higher in normal-weight individuals than in the overweight and obese group (both p<0.01). IgG antibody levels were found significantly lower in people with cardiovascular disease and diabetes mellitus compared with those who did not (p<0.05 and p<0.001, respectively). There was a negative correlation between IgG antibody response values and body mass index and age in Group I (r= −0.336, p<0.001 and r= −0.307, p<0.001, respectively).

CONCLUSION:

IgG antibody values decrease with age and with increasing body mass index. The presence of comorbidities (i.e., diabetes mellitus and cardiovascular disease) decreased COVID-19 IgG antibody values.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: COVID-19 Type of study: Risk factors Limits: Adult / Humans Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Tekirdag˘ Namik Kemal University/TR

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Full text: Available Index: LILACS (Americas) Main subject: COVID-19 Type of study: Risk factors Limits: Adult / Humans Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Tekirdag˘ Namik Kemal University/TR