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Fatty acid-binding protein 4 circulating levels in non-segmental vitiligo
Farag, Azza Gaber Antar; Badr, Eman A. E; El-Shafey, Asmaa El-Shafey Soliman; Elshaib, Mustafa Elsayed.
  • Farag, Azza Gaber Antar; Menoufia University. Andrology and S.T.Ds, Faculty of Medicine. Shebin AlKom. EG
  • Badr, Eman A. E; Menoufia University. Medical Biochemistry and Molecular Biology Department. Faculty of Medicine. Shebin AlKom. EG
  • El-Shafey, Asmaa El-Shafey Soliman; General Hospital. Dermatology, Ministry of Health. Shebin AlKom. EG
  • Elshaib, Mustafa Elsayed; Menoufia University. Faculty of Medicine. Shebin AlKom. EG
An. bras. dermatol ; 97(1): 28-36, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1360088
ABSTRACT
Abstract

Background:

Vitiligo is an acquired and progressive mucocutaneous disease resulting from the loss of active epidermal melanocytes. Metabolic syndrome (MetS) affects about 25% of the world's population and is linked to inflammatory skin diseases including vitiligo. Fatty AcidBinding Protein 4 (FABP4) is an intracellular lipid chaperone. FABP4 is closely associated with MetS.

Objectives:

To evaluate the serum level of FABP4 in vitiligo patients and its relation to MetS in the investigated cases.

Methods:

This case control study was conducted on 45 patients having non segmental vitiligo and 45 matched controls. Their lipid profile, blood glucose and serum FABP4 levels were measured.

Results:

There were significant elevations in FABP4 (p < 0.001), cholesterol (p < 0.001), triglycerides (p = 0.005), and glucose (fasting [p = 0.001] and 2 hours post prandial [p < 0.001]) levels in patients in comparison with controls. MetS was significantly more prevalent among vitiligo patients (p < 0.001) and associated with high FABP4 serum levels (p = 0.037). In vitiligo patients, there were significant positive correlations between FABP4 serum levels and triglycerides (p = 0.047), cholesterol (p = 0.001) and LDL (p = 0.001) levels and negative correlation regarding HDL level (p = 0.009). FABP4 level was a significantly good diagnostic test for early detection of vitiligo (p < 0.001). Study

limitations:

The small number of studied subjects.

Conclusions:

FABP4 may play an active role in the disease process of vitiligo that could be mediated through associated dyslipidemia and hyperglycemia. FABP4 may be a marker of vitiligo helping in its early diagnosis, but it does not appear to be useful for determining vitiligo severity, activity or associated MetS.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Metabolic Syndrome / Fatty Acid-Binding Proteins Type of study: Observational study / Risk factors / Screening study Limits: Humans Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2022 Type: Article Affiliation country: Egypt / Suriname Institution/Affiliation country: General Hospital/EG / Menoufia University/EG

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Full text: Available Index: LILACS (Americas) Main subject: Metabolic Syndrome / Fatty Acid-Binding Proteins Type of study: Observational study / Risk factors / Screening study Limits: Humans Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2022 Type: Article Affiliation country: Egypt / Suriname Institution/Affiliation country: General Hospital/EG / Menoufia University/EG