Fatty acid-binding protein 4 circulating levels in non-segmental vitiligo
An. bras. dermatol
;
97(1): 28-36, Jan.-Feb. 2022. tab, graf
Article
in English
| LILACS
| ID: biblio-1360088
ABSTRACT
Abstract Background:
Vitiligo is an acquired and progressive mucocutaneous disease resulting from the loss of active epidermal melanocytes. Metabolic syndrome (MetS) affects about 25% of the world's population and is linked to inflammatory skin diseases including vitiligo. Fatty AcidBinding Protein 4 (FABP4) is an intracellular lipid chaperone. FABP4 is closely associated with MetS.Objectives:
To evaluate the serum level of FABP4 in vitiligo patients and its relation to MetS in the investigated cases.Methods:
This case control study was conducted on 45 patients having non segmental vitiligo and 45 matched controls. Their lipid profile, blood glucose and serum FABP4 levels were measured.Results:
There were significant elevations in FABP4 (p < 0.001), cholesterol (p < 0.001), triglycerides (p = 0.005), and glucose (fasting [p = 0.001] and 2 hours post prandial [p < 0.001]) levels in patients in comparison with controls. MetS was significantly more prevalent among vitiligo patients (p < 0.001) and associated with high FABP4 serum levels (p = 0.037). In vitiligo patients, there were significant positive correlations between FABP4 serum levels and triglycerides (p = 0.047), cholesterol (p = 0.001) and LDL (p = 0.001) levels and negative correlation regarding HDL level (p = 0.009). FABP4 level was a significantly good diagnostic test for early detection of vitiligo (p < 0.001). Studylimitations:
The small number of studied subjects.Conclusions:
FABP4 may play an active role in the disease process of vitiligo that could be mediated through associated dyslipidemia and hyperglycemia. FABP4 may be a marker of vitiligo helping in its early diagnosis, but it does not appear to be useful for determining vitiligo severity, activity or associated MetS.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Metabolic Syndrome
/
Fatty Acid-Binding Proteins
Type of study:
Observational study
/
Risk factors
/
Screening study
Limits:
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2022
Type:
Article
Affiliation country:
Egypt
/
Suriname
Institution/Affiliation country:
General Hospital/EG
/
Menoufia University/EG
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