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Is the Wistar Rat a more Suitable Normotensive Control for SHR to Test Blood Pressure and Cardiac Structure and Function?
Rezende, Leonardo Mateus Teixeira de; Soares, Leôncio Lopes; Drummond, Filipe Rios; Suarez, Pedro Zavagli; Leite, Luciano; Rodrigues, Joel Alves; Leal, Tiago; Favarato, Lukiya; Reis, Emily Correna Carlo; Favarato, Evandro; Carneiro Júnior, Miguel; Natali, Antônio José; Coimbra, Cândido; Gomes, Thales Prímola.
  • Rezende, Leonardo Mateus Teixeira de; Universidade Federal de Viçosa. Viçosa. BR
  • Soares, Leôncio Lopes; Universidade Federal de Viçosa. Viçosa. BR
  • Drummond, Filipe Rios; Universidade Federal de Viçosa. Viçosa. BR
  • Suarez, Pedro Zavagli; Universidade Federal de Viçosa. Viçosa. BR
  • Leite, Luciano; Universidade Federal de Viçosa. Viçosa. BR
  • Rodrigues, Joel Alves; Universidade Federal de Viçosa. Viçosa. BR
  • Leal, Tiago; Universidade Federal de Viçosa. Viçosa. BR
  • Favarato, Lukiya; Universidade Federal de Viçosa. Viçosa. BR
  • Reis, Emily Correna Carlo; Universidade Federal de Viçosa. Viçosa. BR
  • Favarato, Evandro; Universidade Federal de Viçosa. Viçosa. BR
  • Carneiro Júnior, Miguel; Universidade Federal de Viçosa. Viçosa. BR
  • Natali, Antônio José; Universidade Federal de Viçosa. Viçosa. BR
  • Coimbra, Cândido; Universidade Federal de Minas Gerais. Belo Horizonte. BR
  • Gomes, Thales Prímola; Universidade Federal de Viçosa. Viçosa. BR
Int. j. cardiovasc. sci. (Impr.) ; 35(2): 161-171, Mar.-Apr. 2022. tab, graf
Article in English | LILACS | ID: biblio-1364975
ABSTRACT
Abstract

Background:

There are divergences in the literature regarding the experimental model (Wistar-WIS or Wistar Kyoto-WKY) to be used as a Spontaneously Hypertensive Rat (SHR) control. The characterization of these models in terms of cardiovascular parameters provides researchers with important tools at the time of selection and application in scientific research.

Objective:

The aim of this study was to evaluate the use of WIS and WKY as a Spontaneously Hypertensive Rat (SHR) control by assessing the long-term behavior of blood pressure and cardiac structure and function in these strains.

Methods:

To this end, WIS, WKY, and SHR underwent longitudinal experiments. Blood pressure and body mass were measured every two weeks from the 8th to the 72nd. Echocardiographic analysis was performed in all groups with 16, 48, and 72 weeks of life. After having applied the normality test, the Two-Way ANOVA of repeated measures followed by the Tukey post hoc test was used. A significance level of 5% was established.

Results:

The WIS group showed higher body mass (p<0.05), while the WKY and SHR presented higher body mass variation over time (p<0.05). SHR exhibited increased values of systolic, diastolic, and mean blood pressure when compared to WKY and WIS, whereas the WKY generally showed higher values than WIS (p<0.05). Regarding the cardiac function, SHR showed reduced values, while the WKY presented an early decrease when compared to WIS with aging (p<0.05).

Conclusion:

WIS is a more suitable normotensive control for SHR than WKY in experiments to test blood pressure and cardiac structure and function.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Arterial Pressure / Heart / Hypertension Type of study: Observational study Limits: Animals Language: English Journal: Int. j. cardiovasc. sci. (Impr.) Journal subject: Cardiology Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / Universidade Federal de Viçosa/BR

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Full text: Available Index: LILACS (Americas) Main subject: Arterial Pressure / Heart / Hypertension Type of study: Observational study Limits: Animals Language: English Journal: Int. j. cardiovasc. sci. (Impr.) Journal subject: Cardiology Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / Universidade Federal de Viçosa/BR