Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil
J. venom. anim. toxins incl. trop. dis
;
28: e20210074, 2022. ilus
Article
in English
| LILACS, VETINDEX
| ID: biblio-1365077
ABSTRACT
Background:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. Case presentation We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen.Conclusion:
The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.(AU)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Immunohistochemistry
/
SARS-CoV-2
/
COVID-19
/
Antigens
Type of study:
Prognostic study
Limits:
Animals
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Year:
2022
Type:
Article
Institution/Affiliation country:
Federal Rural University of Rio de Janeiro/BR
/
Federal University of Mato Grosso/BR
/
Federal University of Paraná/BR
/
Oregon State University/US
/
Purdue University/US
/
University of Washington/US
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