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Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil
Jarrah, Samar Afif; Kmetiuk, Louise Bach; Carvalho, Otávio Valério de; Sousa, Alessandra Tammy Hayakawa Ito de; Souza, Valeria Regia Franco; Nakazato, Luciano; Colodel, Edson Moleta; Santos, Andrea Pires dos; Pettan-Brewer, Christina; Hahn, Rosane Christine; Slhessarenko, Renata Dezengrini; Ubiali, Daniel Guimarães; Pereira, Asheley Henrique Barbosa; Morais, Helio Autran de; Biondo, Alexander Welker; Dutra, Valéria.
  • Jarrah, Samar Afif; Federal University of Mato Grosso. College of Veterinary Medicine. Department of Veterinary Medicine. Cuiabá. BR
  • Kmetiuk, Louise Bach; Federal University of Paraná. Curitiba. BR
  • Carvalho, Otávio Valério de; Federal University of Paraná. Curitiba. BR
  • Sousa, Alessandra Tammy Hayakawa Ito de; Federal University of Mato Grosso. College of Veterinary Medicine. Department of Veterinary Medicine. Cuiabá. BR
  • Souza, Valeria Regia Franco; Federal University of Mato Grosso. College of Veterinary Medicine. Department of Veterinary Medicine. Cuiabá. BR
  • Nakazato, Luciano; Federal University of Mato Grosso. College of Veterinary Medicine. Department of Veterinary Medicine. Cuiabá. BR
  • Colodel, Edson Moleta; Federal University of Mato Grosso. College of Veterinary Medicine. Department of Veterinary Medicine. Cuiabá. BR
  • Santos, Andrea Pires dos; Purdue University. College of Veterinary Medicine. Department of Comparative Pathobiology. West Lafayette. US
  • Pettan-Brewer, Christina; University of Washington. School of Medicine. Department of Comparative Medicine. Seattle. US
  • Hahn, Rosane Christine; Federal University of Mato Grosso. Medical Science Faculty. Cuiabá. BR
  • Slhessarenko, Renata Dezengrini; Federal University of Mato Grosso. Júlio Muller University Hospital. Cuiabá. BR
  • Ubiali, Daniel Guimarães; Federal Rural University of Rio de Janeiro. Veterinary Institute. Department of Epidemiology and Public Health. Seropedica. BR
  • Pereira, Asheley Henrique Barbosa; Federal Rural University of Rio de Janeiro. Veterinary Institute. Department of Epidemiology and Public Health. Seropedica. BR
  • Morais, Helio Autran de; Oregon State University. Department of Clinical Sciences. Corvallis. US
  • Biondo, Alexander Welker; Federal University of Paraná. Department of Veterinary Medicine. Curitiba. BR
  • Dutra, Valéria; Federal University of Mato Grosso. College of Veterinary Medicine. Department of Veterinary Medicine. Cuiabá. BR
J. venom. anim. toxins incl. trop. dis ; 28: e20210074, 2022. ilus
Article in English | LILACS, VETINDEX | ID: biblio-1365077
ABSTRACT

Background:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. Case presentation We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen.

Conclusion:

The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.(AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Immunohistochemistry / SARS-CoV-2 / COVID-19 / Antigens Type of study: Prognostic study Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: J. venom. anim. toxins incl. trop. dis Year: 2022 Type: Article Institution/Affiliation country: Federal Rural University of Rio de Janeiro/BR / Federal University of Mato Grosso/BR / Federal University of Paraná/BR / Oregon State University/US / Purdue University/US / University of Washington/US

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Full text: Available Index: LILACS (Americas) Main subject: Immunohistochemistry / SARS-CoV-2 / COVID-19 / Antigens Type of study: Prognostic study Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: J. venom. anim. toxins incl. trop. dis Year: 2022 Type: Article Institution/Affiliation country: Federal Rural University of Rio de Janeiro/BR / Federal University of Mato Grosso/BR / Federal University of Paraná/BR / Oregon State University/US / Purdue University/US / University of Washington/US