The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials
Pesqui. bras. odontopediatria clín. integr
;
22: e210046, 2022. tab, graf
Article
in English
| LILACS, BBO
| ID: biblio-1365231
ABSTRACT
ABSTRACT Objective To describe and evaluate the xylitol products' applicability and its effects in the health area worldwide utilizing a bibliometric analysis from randomized controlled trials (RCT) with humans. Material and Methods Electronic searches were carried out in Medline/PubMed, Scopus, Cochrane Library, Web of Science, and VHL databases. The main data extracted were year, area of applicability, type of treatment, country, journal, xylitol posology and concentration, presentation form, outcomes, and effects. Results From 1476 studies, 257 were included. These studies were published between 1973-2021. The majority was carried out in dentistry (73.9%) and under preventive treatment (67.4%). These studies were developed in the USA (15.4%) and published in Caries Research (6.6%). The posology and concentration ranged between 0.004-67 g/day and 0.002-100%, respectively. The xylitol is usually used in the chewing gum form (44.0%), and for antimicrobial activity evaluation (38.5%). A positive effect was observed in 204 studies (79.3%) and was associated with xylitol concentration ≥ 15(p=0.007). Side effects were reported in 8.2and were associated with posology ≥ 5 g/day (p=0.03). Conclusion Most studies with xylitol were conducted to prevent diseases in the dentistry field. The chewing gum form and antimicrobial activity evaluation were more frequent. Most xylitol products have a positive effect, and few studies report side effects.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Therapeutics
/
Xylitol
/
Bibliometrics
/
Randomized Controlled Trials as Topic
/
Chewing Gum
/
Anti-Infective Agents
Type of study:
Controlled clinical trial
/
Evaluation studies
/
Systematic reviews
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Pesqui. bras. odontopediatria clín. integr
Journal subject:
Dentistry
Year:
2022
Type:
Article
Affiliation country:
Brazil
/
Spain
Institution/Affiliation country:
Federal University of Paraíba/BR
/
Federal University of Rio de Janeiro/BR
/
Universitat Politècnica de València/ES
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