Your browser doesn't support javascript.
loading
Blood count and fasting blood glucose level in the assessment of prognosis and survival in advanced cervical cancer
Mota, Sâmela Daiere Soares; Otaño, Sérgio Santana; Murta, Eddie Fernando Candido; Nomelini, Rosekeila.
  • Mota, Sâmela Daiere Soares; Universidade Federal do Triângulo Mineiro. Research Institute of Oncology. Department of Gynecology and Obstetrics. Uberaba. BR
  • Otaño, Sérgio Santana; Universidade Federal do Triângulo Mineiro. Research Institute of Oncology. Department of Gynecology and Obstetrics. Uberaba. BR
  • Murta, Eddie Fernando Candido; Universidade Federal do Triângulo Mineiro. Research Institute of Oncology. Department of Gynecology and Obstetrics. Uberaba. BR
  • Nomelini, Rosekeila; Universidade Federal do Triângulo Mineiro. Research Institute of Oncology. Department of Gynecology and Obstetrics. Uberaba. BR
Rev. Assoc. Med. Bras. (1992) ; 68(2): 234-238, Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1365363
ABSTRACT
SUMMARY

OBJECTIVE:

The objective of this study was to verify whether the parameters of the blood count and the fasting glucose level before treatment are related to prognosis and survival in cervical cancer (IIB-IVB staging).

METHODS:

Patients with cervical cancer (stages IIB-IVB) were evaluated (n=80). Age, parity, staging, histological grade, histological type, hemoglobin, red blood cells, hematocrit, neutrophil, lymphocyte and platelet counts, red blood cell distribution width, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, fasting glucose levels, overall survival, and disease-free survival were evaluated. The results of laboratory parameters were compared using the Mann-Whitney U test. Receiver operating characteristic curve was used to obtain the area under the curve and determine the best cutoff values for each parameter. Survival was verified by using the Kaplan-Meier method, followed by the log-rank test. The level of significance was ≤0.05.

RESULTS:

Regarding staging, lower hemoglobin values (p=0.0013), red blood cells (p=0.009), hematocrit (p=0.0016), higher leukocytes (p=0.0432), neutrophils (p=0.0176), platelets (p=0.0140), red blood cell distribution width (RDW) (p=0.0073), neutrophil-lymphocyte ratio (p=0.0039), platelet-lymphocyte ratio (p=0.0006), and fasting glucose level (p=0.0278) were found in IIIA-IVB compared with IIB staging. Shorter disease-free survival was associated with hemoglobin ≤12.3 g/dl (p=0.0491), hematocrit ≤38.5% (p=0.05), neutrophil-lymphocyte ratio >2.9 (p=0.0478), and platelet-lymphocyte ratio >184.9 (p=0.0207). Shorter overall survival was associated with hemoglobin ≤12.3 g/dl (p=0.0131), hematocrit ≤38.5% (p=0.0376), neutrophil-lymphocyte ratio >2.9 (p=0.0258), and platelet-lymphocyte ratio >184.9 (p=0.0038).

CONCLUSION:

The analysis of these low-cost and easily accessible parameters could be a way to monitor patients in order to predict treatment failures and act as early as possible.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Blood Glucose / Uterine Cervical Neoplasms Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Triângulo Mineiro/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Blood Glucose / Uterine Cervical Neoplasms Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Triângulo Mineiro/BR