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Resveratrol as an anti-asthmatic agent: could this stilbenoid help against COVID-19 in any way? a meta-analysis / Resveratrol como agente antiasmático: ¿podría este estilbenoide ayudar contra el COVID-19 de alguna manera? un metaanálisis
Parlar, Ali; Muñoz-Acevedo, Ammer; Üçkardes, Fatih; Jaimes, Luisauris; Aneva, Ina; Morales, Bernardo; Unis, Amina; Rodríguez, Maite; Yumrutas, Onder; Vinet, Raúl; Bungau, Simona; Martínez, José L.
  • Parlar, Ali; University of Adiyaman. Faculty of Medical. Department of Pharmacology. Adiyaman. TR
  • Muñoz-Acevedo, Ammer; Universidad del Norte. Department of Chemistry and Biology. Barranquilla. CO
  • Üçkardes, Fatih; Adiyaman University. Faculty of Medicine. Department of Biostatistics. Adiyaman. TR
  • Jaimes, Luisauris; Universidad de Santiago de Chile. Faculty of Chemistry and Biology. Department of Biology. Santiago. CL
  • Aneva, Ina; Bulgarian Academy of Sciences. Institute of Biodiversity and Ecosystem Research. BG
  • Morales, Bernardo; Universidad de Santiago de Chile. Faculty of Chemistry and Biology. Department of Biology. Santiago. CL
  • Unis, Amina; Ras Al Khaimah Medical and Health Sciences University. Ras Al Khaimah. AE
  • Rodríguez, Maite; Andrés Bello University. Faculty of Medicine. School of Chemistry and Pharmacy. Santiago. CL
  • Yumrutas, Onder; University of Adiyaman. Faculty of Medical. Department of Pharmacology. Adiyaman. TR
  • Vinet, Raúl; Universidad de Valparaíso. Faculty of Pharmacy. Laboratory of Pharmacology. Valparaíso. CL
  • Bungau, Simona; University of Oradea. Faculty of Medicine and Pharmacy. Department of Pharmacy. Oradea. RO
  • Martínez, José L; Universidad de Santiago de Chile. Development and Innovation. Vice Rectory of Investigation. Santiago. CL
Bol. latinoam. Caribe plantas med. aromát ; 20(5): 463-481, sept. 2021. ilus, tab
Article in English | LILACS | ID: biblio-1368606
ABSTRACT
Resveratrol is a phenolic phytoconstituent found in many plants. This molecule has always caught the attention of scientists because of biological potentials such as inhibition of inflammation, oxidative stress and platelet aggregation as well as to prevent/protect against cardiovascular and neurodegenerative disease/disorders. Literature search have been conducted over resveratrol in covid-19 and asthma studies published in Pubmed and Google Scholars until 30 September 2020. The criteria used in the literature review were determined and were reviewed works on resveratrol including 368 articles and 47 articles on covid-19 and asthma, respectively. As a result of meta-analysis, TNF-α values of the studies showed a significant difference (heterogeneity) of I2=68.39% from each other in total (Cohran Q6.33, p<0.0423). This study shows that resveratrol would have a potential to reduce ARDS symptoms, by suppressing the cytokine storm and severe inflammation caused by SARS-CoV-2, and by showing strong activity against various types of DNA/RNA viruses.
RESUMEN
El resveratrol es un fitoconstituyente fenólico que se encuentra en muchas plantas. Esta molécula siempre ha llamado la atención de los científicos debido a sus potenciales biológicos como la inhibición de la inflamación, el estrés oxidativo y la agregación plaquetaria, así como para prevenir/proteger contra enfermedades/trastornos cardiovasculares y neurodegenerativos. Se han realizado búsquedas bibliográficas sobre resveratrol en covid-19 y estudios sobre asma publicados en Pubmed y Google Scholars hasta el 30 de septiembre de 2020. Se determinaron los criterios utilizados en la revisión bibliográfica y se revisaron trabajos sobre resveratrol que incluyen 368 artículos y 47 artículos sobre covid-19 y asma, respectivamente. Como resultado del metanálisis, los valores de TNF-α de los estudios mostraron una diferencia significativa (heterogeneidad) de I2=68,39% entre sí en total (Cohran Q 6,33, p<0,0423). Este estudio muestra que el resveratrol podría reducir los síntomas del ARDS al suprimir la tormenta de citocinas y la inflamación severa causada por el SARS-CoV-2, y al mostrar una fuerte actividad contra varios tipos de virus de ADN/ARN.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Asthma / Resveratrol / COVID-19 Type of study: Systematic reviews Limits: Humans Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2021 Type: Article Affiliation country: Bulgaria / Chile / Colombia / Romania / Turkey / United Arab Emirates Institution/Affiliation country: Adiyaman University/TR / Andrés Bello University/CL / Bulgarian Academy of Sciences/BG / Ras Al Khaimah Medical and Health Sciences University/AE / Universidad de Santiago de Chile/CL / Universidad de Valparaíso/CL / Universidad del Norte/CO / University of Adiyaman/TR / University of Oradea/RO

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Full text: Available Index: LILACS (Americas) Main subject: Asthma / Resveratrol / COVID-19 Type of study: Systematic reviews Limits: Humans Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2021 Type: Article Affiliation country: Bulgaria / Chile / Colombia / Romania / Turkey / United Arab Emirates Institution/Affiliation country: Adiyaman University/TR / Andrés Bello University/CL / Bulgarian Academy of Sciences/BG / Ras Al Khaimah Medical and Health Sciences University/AE / Universidad de Santiago de Chile/CL / Universidad de Valparaíso/CL / Universidad del Norte/CO / University of Adiyaman/TR / University of Oradea/RO