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High-intensity resistance exercise and Schinus terenbinthifolius supplementation attenuate oxidative stress and muscle damage biomarkers / El ejercicio de resistencia de alta intensidad y la suplementación con Schinus terenbinthifolius atenúan los biomarcadores del estrés oxidativo y daño muscular
Vieira-Souza, Lucio Marques; Marçal, Anderson Carlos; dos-Santos, Jymmys; Lopes Aidar, Felipe José; dos-Santos, Samuel Bruno; de Santana Silva, André Luiz; Costa Reis, Gracielle; Santana de Carvalho, George Franklin; de Souza, Raphael Fabrício; Tavares dos Santos, Darlan; Sorbazo Soto, Dany Alexis; Brito, Ciro José.
  • Vieira-Souza, Lucio Marques; Federal University of Juiz de Fora. Governador Valadares. BR
  • Marçal, Anderson Carlos; State University of Minas Gerais. Passos. BR
  • dos-Santos, Jymmys; State University of Minas Gerais. Passos. BR
  • Lopes Aidar, Felipe José; State University of Minas Gerais. Passos. BR
  • dos-Santos, Samuel Bruno; Federal University of Sergipe. Northeast Network in Biotechnology. São Cristóvão. BR
  • de Santana Silva, André Luiz; University of Porto-FADEUP. Faculty of Sport. Porto. PT
  • Costa Reis, Gracielle; State University of Minas Gerais. Passos. BR
  • Santana de Carvalho, George Franklin; State University of Minas Gerais. Passos. BR
  • de Souza, Raphael Fabrício; State University of Minas Gerais. Passos. BR
  • Tavares dos Santos, Darlan; Federal University of the state of Rio de Janeiro. Rio de Janeiro. BR
  • Sorbazo Soto, Dany Alexis; Federal University of Juiz de Fora. Governador Valadares. BR
  • Brito, Ciro José; Federal University of Juiz de Fora. Governador Valadares. BR
Int. j. morphol ; 40(3): 781-788, jun. 2022. ilus
Article in English | LILACS-Express | LILACS | ID: biblio-1385681
Responsible library: CL1.1
ABSTRACT

SUMMARY:

High-intensity physical exercises can cause oxidative stress and muscle damage. Several medicinal plants have been used as antioxidant and anti-inflammatory agents. The present study evaluated high-intensity resistance exercise (HIRE) associated with Schinus Terebentifholius ethanolic extract (EE) on oxidative parameters and muscle damage in Wistar rats. Animals were divided into 04 groups (n=10/group) 1. Control (CG) - animals that did not undergo HIRE and were treated with vehicle (distilled water, orally); 2. Acute exercise (AE) - animals submitted to acute exercise session; 3. Exercise + vehicle (EV) - animals that underwent HIRE and were treated with vehicle and 4. Exercise + extract (EX) animals administered with Schinus terebenthifolius EE (100mg/Kg, orally) and submitted to the exercise session. Schinus terebenthifolius EE showed high in vitro antioxidant activity (13.88 ± 0.36 mg/mL). Before the experimental period, lactate was measured at pre and post moments of AE (p<0.0001) and EX (p<0.0001) groups. After the acute session, the following were evaluated oxidative stress {malondialdehyde (MDA), sulfhydryl groups (SH) and ferric reducing antioxidant power (FRAP)}, muscle damage (creatine kinase (CK) and lactate dehydrogenase (LDH)), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In the in vivo analyses of the EX group compared to AE and EV groups, respectively hepatic (MDA p<0.0001 and SH p=0.0033, in both; FRAP p=0.0011 and p=0.0047), muscle (MDA, SH and FRAP p<0.0001, in both; CK p=0.0001 and p<0.0001; LDH p<0.0001, in both), serum levels (MDA p=0.0003, p=0.0012, SH p=0.0056, p=0.0200, FRAP p=0.0017 and p=0.0165) were significant. There was no significant difference in ALT and AST markers. It could be concluded that Schinus terebenthifolius EE associated with HIRE attenuated oxidative stress and muscle damage in rats.
RESUMEN
RESUMEN Los ejercicios físicos de alta intensidad pueden causar estrés oxidativo y daño muscular. Varias plantas medicinales se han utilizado como agentes antioxidantes y antiinflamatorios. El presente estudio evaluó el ejercicio de resistencia de alta intensidad (HIRE) asociado con el extracto etanólico (EE) de Schinus terebentifholius sobre los parámetros oxidativos y el daño muscular en ratas Wistar. Los animales se dividieron en 4 grupos (n=10/grupo) 1. Control (GC) - animales que no se sometieron a HIRE y fueron tratados con vehículo (agua destilada, por vía oral); 2. Ejercicio agudo (AE) - animales sometidos a sesión de ejercicio agudo; 3. Ejercicio + vehículo (EV) - animales que se sometieron a HIRE y fueron tratados con vehículo y 4. Ejercicio + extracto (EX) animales administrados con Schinus terebenthifolius EE (100 mg/kg, por vía oral) y sometidos a la sesión de ejercicio. Schinus terebenthifolius EE mostró una alta actividad antioxidante in vitro (13,88 ± 0,36 mg/mL). Antes del período experimental, se midió el lactato en los momentos pre y post de los grupos AE (p<0,0001) y EX (p<0,0001). Tras la sesión aguda, se evaluaron el estrés oxidativo malondialdehído (MDA), grupos sulfhidrilo (SH) y poder antioxidante reductor férrico (FRAP), daño muscular (creatina quinasa (CK) y lactato deshidrogenasa (LDH)), alanina aminotransferasa (ALT) y aspartato aminotransferasa (AST). En los análisis in vivo del grupo EX frente a los grupos AE y EV, respectivamente hepático (MDA p<0,0001 y SH p=0,0033, en ambos; FRAP p=0,0011 y p=0,0047), muscular (MDA, SH y FRAP p<0,0001, en ambos; CK p=0,0001 y p<0,0001; LDH p<0,0001, en ambos), niveles séricos (MDA p=0,0003, p=0,0012, SH p=0,0056, p=0,0200, FRAP p=0,0017 y p=0,0165) fueron significativas. No hubo diferencia significativa en los marcadores ALT y AST. Se podría concluir que Schinus terebenthifolius EE asociado con HIRE atenuó el estrés oxidativo y el daño muscular en ratas.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Exercise / Anacardiaceae / Antioxidants Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2022 Type: Article Affiliation country: Brazil / Portugal Institution/Affiliation country: Federal University of Juiz de Fora/BR / Federal University of Sergipe/BR / Federal University of the state of Rio de Janeiro/BR / State University of Minas Gerais/BR / University of Porto-FADEUP/PT

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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Exercise / Anacardiaceae / Antioxidants Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2022 Type: Article Affiliation country: Brazil / Portugal Institution/Affiliation country: Federal University of Juiz de Fora/BR / Federal University of Sergipe/BR / Federal University of the state of Rio de Janeiro/BR / State University of Minas Gerais/BR / University of Porto-FADEUP/PT