A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures
Braz. j. oral sci
;
21: e226585, jan.-dez. 2022. ilus
Article
in English
| LILACS, BBO
| ID: biblio-1393018
ABSTRACT
Aim:
This study aimed to systematically review existing literature regarding the association between dental proceduressuch as tooth extractions and periodontal therapyand occurrence of medication-related osteonecrosis of the jaw (MRONJ) in individuals using bone-modifying drugs.Methods:
Search strategies were performed in PubMed, Scopus, Web of Science and Cochrane Library for a timeframe ending in December 2021. Study selection, data extraction and risk of bias were analyzed independently by two researchers. Three meta-analyses were performed, estimating the crude risk ratio (RR), the adjusted odds ratio (OR) and the adjusted hazard ratio (HR) for the association between tooth extraction and MRONJ.Results:
Of the 1,654 studies initially retrieved, 17 were ultimately included. The majority of patients with MRONJ in these studies were female, with a mean age of 64 years. Zoledronic acid was the most commonly used drug among patients with MRONJ, and cancer was the most frequent underlying health condition. Regarding the performed meta-analyses, crude and adjusted analyses demonstrated that tooth extraction increased the risk for MRONJ by 4.28 (95% confidence interval [95%CI] 1.7310.58), the OR for MRONJ by 26.94 (95%CI 4.17174.17), and the HR for MRONJ by 9.96 (95%CI 4.0424.55).Conclusion:
It was concluded that performing dental procedures, especially tooth extraction, in patients using bone-modifying drugs increased the risk of MRONJ occurrence and, therefore, should be avoided. Further studies, using adjusted data, are warranted
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Surgery, Oral
/
Bone Density Conservation Agents
/
Bisphosphonate-Associated Osteonecrosis of the Jaw
/
Mandible
Type of study:
Systematic reviews
Language:
English
Journal:
Braz. j. oral sci
Journal subject:
Dentistry
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Arthur Sá Earp Neto University/BR
/
Federal University of Pelotas/BR
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