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Smart Spectrophotometric Methods for Concurrent Determination of Furosemide and Spironolactone Mixture in Their Pharmaceutical Dosage Forms
Lotfy, Hayam M; El-Hanboushy, Sara; Fayz, Yassmin M; Abdelkawy, Mohammed.
  • Lotfy, Hayam M; Future University in Egypt. Faculty of Pharmacutical sciences and pharmaceutical industries. Pharmaceutical Chemistry Department. EG
  • El-Hanboushy, Sara; Future University in Egypt. Faculty of Pharmacutical sciences and pharmaceutical industries. Pharmaceutical Chemistry Department. EG
  • Fayz, Yassmin M; Cairo University. Faculty of Pharmacy. Analytical Chemistry Department. EG
  • Abdelkawy, Mohammed; Future University in Egypt. Faculty of Pharmacutical sciences and pharmaceutical industries. Pharmaceutical Chemistry Department. EG
Braz. J. Pharm. Sci. (Online) ; 58: e19487, 2022. tab, graf
Article in English | LILACS | ID: biblio-1394028
ABSTRACT
Abstract Simple, precise, accurate and specific spectrophotometric methods are progressed and validated for concurrent analysis of Furosemide (FUR) and Spironolactone (SPR) in their combined dosage form depend on spectral analysis procedures. Furosemide (FUR) in the binary mixture could be analyzed at its λmax 274 nm using its recovered zero order absorption spectrum using constant multiplication method (CM). Spironolactone (SPR) in the mixture could be analyzed at its λmax 238 nm by ratio subtraction method (RS). Concurrent determination for FUR and SPR in their mixture could be applied by amplitude modulation method (AM), absorbance subtraction method (AS) and ratio difference (RD). Linearity ranges of FUR and SPR were (2.0µg/mL-22.0 µg/mL) and (3.0µg/mL-30.0 µg/mL), respectively. Specificity of the proposed spectrophotometric methods was examined by analyzing the prepared mixtures in laboratory and was applied successfully for pharmaceutical dosage form analysis which have the cited drugs without additives contribution. The proposed spectrophotometric methods were also validated as per as the guidelines of ICH. Statistical comparison was performed between the obtained results with those from the official methods of the cited drugs, using one-way ANOVA, F-test and student t-test. The results are exhibiting insignificant difference concerning precision and accuracy
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Full text: Available Index: LILACS (Americas) Main subject: Spectrophotometry / Spironolactone / Pharmaceutical Preparations / Furosemide Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Egypt Institution/Affiliation country: Cairo University/EG / Future University in Egypt/EG

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Full text: Available Index: LILACS (Americas) Main subject: Spectrophotometry / Spironolactone / Pharmaceutical Preparations / Furosemide Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Egypt Institution/Affiliation country: Cairo University/EG / Future University in Egypt/EG