Diagnostic value of serum levels of galanin and obestatin in patients with gastric cancer
Rev. Assoc. Med. Bras. (1992)
;
68(7): 888-892, July 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1394590
ABSTRACT
SUMMARY OBJECTIVE:
Gastric cancer ranks the third among the cancer-related deaths. It is diagnosed at advanced stage in many patients due to malignant proliferation and has a poor prognosis. Currently, no instrument or biomarker has been proven to diagnose the disease before the advanced stages. This study aimed to measure the serum levels of galanin and obestatin, which were examined in various studies including cancer studies, and to discuss their diagnostic value in gastric cancers.METHODS:
In this study, 30 adult patients with gastric cancer and 30 healthy adults in the control group were examined prospectively. The demographic characteristics and serum levels of galanin and obestatin in the patient and control groups were recorded.RESULTS:
The mean serum level of galanin in the patient and control groups was 19.73±5.04 and 35.59±10.94 pg/mL, respectively. The mean serum level of obestatin in the patient and control groups was 40.21±5.82 and 15.15±3.32 ng/mL, respectively. A significant difference was found between the groups (p<0.001).CONCLUSION:
Serum levels of galanin were lower and serum levels of obestatin were higher in patients with gastric cancer compared to the healthy individuals. Serum levels of obestatin and galanin can be used as potential biomarkers in the diagnosis of gastric cancer.
Full text:
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Index:
LILACS (Americas)
Type of study:
Diagnostic study
/
Prognostic study
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992)
Year:
2022
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Atatürk University Faculty of Medicine/TR
/
Muş State Hospital/TR
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