Stress-another possible mechanism of neurotoxicity in neurodegenerative diseases
Int. j. high dilution res
;
21(1): 29-30, May 6, 2022.
Article
in English
| LILACS, HomeoIndex
| ID: biblio-1396556
ABSTRACT
Theliteratureassociatesoxidativestresswiththeproductionoffreeradicals,whichleadtoneurodegeneration.Theypresentinnumerablehypotheses,amongwhichareabnormalitiesinthefunctioningofthehypothalamic-pituitary-adrenalaxis,neurotoxiceffectsandneuronaloxidativedamage.ClinicalobservationhasshownthatinneurodegenerativediseasessuchasMultipleSclerosis(MS)andAmyotrophicLateralSclerosis(ALS)thereisareportofprolonged or violent emotionalstressprecedingthesymptoms.Aims:
UsingtheCarilloComplexSystemsModel,presentsomepossibilitiesonhowstresscancontributetoneurodegeneration.Methodology:
NinecasesofALSandsixcasesofMSwereevaluated,pathologiesalreadyclassifiedasbelongingtosyphilinism.Literaturereviewonstressandneurotoxicitycarriedout.Resultsanddiscussion:
Syphilinism is instability with a predominantly intrinsicorigin to the system with a chronic caracter.This diathesis is characterized by a dissipative deficiency, predominantly hepatic, to the processing of certain elements or potentially toxic substances with exogenous origin or endogenous Such non-processed substances are unstable factors in the system, with greater affinity for certain tissues,like the nervous system. Among the toxins, we find alcohol, esters, formaldehyde, aloe, ketones, aldehydes, etc. The final hepatic metabolism of cortisol results in cortic acids and cortol, which use the same enzymatic system as alcohol, and can be considered syphilinic toxins. Ethanol can act directly at the circadian rhythm, disrupting it and generating stressful substances such as cortisol, regardless of an external event, increasing the toxin level. The inflammatory process generated by the production of free radicals and metabolic abnormalities, including the reduction of neuropeptide Y that modulates inflammatory activity in the nervous system, leads to changes that can result in neurodegeneration.Conclusion:
Inflammation caused by toxins from prolonged/violent emotional stress can lead to several changes in syphilinic individuals, due to failure in the dissipative process, including neurodegeneration.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stress, Psychological
/
Syphilinism in Homeopathy
/
Neurodegenerative Diseases
/
Neurotoxicity Syndromes
Type of study:
Prognostic study
Language:
English
Journal:
Int. j. high dilution res
Journal subject:
Homeopathy
/
Terapias Complementares
Year:
2022
Type:
Article
Affiliation country:
Brazil
/
Portugal
Institution/Affiliation country:
ABRAH/BR
/
Hospital do Servidor Público Municipal de São Paulo/BR
/
UFF/BR
/
UFRJ/BR
/
UNB/BR
/
University of Évora/PT
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