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Assessment of Serum Uric Acid, Urea, and Glucose Levels and Associated Factors among Breast Cancer Patients Attending A Tertiary Hospital in Bahirdar, Ethiopia: A Comparative CrossSectional Study
Tinfash, Kebede; Tadele, Melak; Abu Ali Ibn, Sina; Fasil, Alebachew.
  • Tinfash, Kebede; Department of Medical Laboratory science, Chief Clinical Chemist at Debark hospital. Debark. ET
  • Tadele, Melak; Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences. Gondar. ET
  • Abu Ali Ibn, Sina; Center for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner College and Cooper Roads (Bldg 75), The University of Queensland. Queensland. AU
  • Fasil, Alebachew; Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences. Gondar. ET
Ethiop. j. health sci. (Online) ; 32(6): 1183-1192, 2022.
Article in English | AIM | ID: biblio-1402434
ABSTRACT

BACKGROUND:

Breast cancer is currently become a major public health problem in both developed and developing regions, it is one of the most common surgical problems in Ethiopia. Therefore, this study assessed serum uric acid, urea, and glucose levels and associated factors among benign, malignant breast cancer patients and apparently healthy women attending at Felege-Hiwot comprehensive Specialized Hospital.

METHODS:

Hospital based comparative cross-sectional study was conducted among benign, malignant breast cancer patients and apparently healthy women attending at Felege-Hiwot Comprehensive Specialized Hospital. Out of 178 study participants 66 benign and 23 malignant fine needle aspirate cytology confirmed breast cancer patients and 89 apparently healthy women, included. Multivariable logistic regression models used to measure the strength of associations. A P value of < 0.05 was considered statistically significant.

RESULTS:

Majority of the study participants, 81(91%) controls, 55(83.3%) benign, and 17(73.9%) malignant cases were premenopausal. Serum glucos144.47±74.35 and uric acid 6.84±2.54 levels were significantly elevated in malignant cases than control (p-value< 0.05). Patients with malignant status were 4.38 times more likely to have hyperglycemia (AOR=4.38, 95%CI 1.98-19.97) and 5.53 times more likely have hyperuricemia (AOR=20.43-95% CI 6.80- 61.23), 4 times more likely to have uremia (AOR=4.09, 95% CI 1.06-15.91) compared to apparently healthy women.

CONCLUSION:

Serum glucose, and uric acid levels were significantly higher in malignant and benign cases compared with apparently healthy women. Family history of breast cancer, body mass index, systolic hypertension, comorbidity, residence and menopausal status were significantly associated with hyperglycemia, uremia and hyperuricemia.
Subject(s)


Full text: Available Index: AIM (Africa) Main subject: Breast Neoplasms / Glucose Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Ethiop. j. health sci. (Online) Year: 2022 Type: Article Institution/Affiliation country: Center for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner College and Cooper Roads (Bldg 75), The University of Queensland/AU / Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences/ET / Department of Medical Laboratory science, Chief Clinical Chemist at Debark hospital/ET

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Full text: Available Index: AIM (Africa) Main subject: Breast Neoplasms / Glucose Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Ethiop. j. health sci. (Online) Year: 2022 Type: Article Institution/Affiliation country: Center for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner College and Cooper Roads (Bldg 75), The University of Queensland/AU / Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences/ET / Department of Medical Laboratory science, Chief Clinical Chemist at Debark hospital/ET