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Antibacterial effect of isoeugenol against Pseudomonas aeruginosa
Galvão, José Lucas Ferreira Marques; Rosa, Lyvia Layanne Silva; Diniz Neto, Hermes; Silva, Daniele de Figueredo; Nóbrega, Jefferson Rodrigues; Cordeiro, Laísa Vilar; Figueiredo, Pedro Thiago Ramalho de; Andrade Júnior, Francisco Patricio de; Oliveira Filho, Abrahão Alves de; Lima, Edeltrudes de Oliveira.
  • Galvão, José Lucas Ferreira Marques; Federal University of Paraíba. Department of Pharmaceutical Science. João Pessoa. BR
  • Rosa, Lyvia Layanne Silva; Federal University of Paraíba. Department of Pharmaceutical Science. João Pessoa. BR
  • Diniz Neto, Hermes; Federal University of Paraíba. Department of Pharmaceutical Science. João Pessoa. BR
  • Silva, Daniele de Figueredo; Federal University of Paraíba. Department of Pharmaceutical Science. João Pessoa. BR
  • Nóbrega, Jefferson Rodrigues; Federal University of Paraíba. Department of Pharmaceutical Science. João Pessoa. BR
  • Cordeiro, Laísa Vilar; Federal University of Paraíba. Department of Pharmaceutical Science. João Pessoa. BR
  • Figueiredo, Pedro Thiago Ramalho de; Federal University of Paraíba. Department of Pharmaceutical Science. João Pessoa. BR
  • Andrade Júnior, Francisco Patricio de; Federal University of Paraíba. Department of Pharmaceutical Science. João Pessoa. BR
  • Oliveira Filho, Abrahão Alves de; Federal University of Campina Grande. Patos. BR
  • Lima, Edeltrudes de Oliveira; Federal University of Paraíba. Department of Pharmaceutical Science. João Pessoa. BR
Braz. J. Pharm. Sci. (Online) ; 58: e20075, 2022. tab, graf
Article in English | LILACS | ID: biblio-1403710
ABSTRACT
Abatsract Pseudomonas aeruginosa is an important nosocomial pathogen and its clinical importance is mainly related to nosocomial infections. Increased rates of bacterial resistance in recent years has led WHO to publish a global priority list to guide research and discovery of new antibiotics, where P. aeruginosa is among the group of bacteria for which there is a critical level of priority for new drugs to be discovered. In this context, isoeugenol appears as an interesting alternative and the objective of this study was to investigate its action against P. aeruginosa. Isoeugenol presented significant antibacterial activity, with minimum inhibitory concentration (MIC) of 64µg/mL and minimum bactericidal concentration (MBC) of 128µg/mL, and was considered bactericidal against this species. Molecular docking revealed interactions that suggest that isoeugenol may bind to the enzyme Penicillin-Binding Protein 3 and interfere with the bacterial cell wall synthesis process. This study reinforces the antibacterial potential of this compound and emphasizes that more studies are needed in order to better investigate its mechanism of antibacterial action.
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Full text: Available Index: LILACS (Americas) Main subject: Pseudomonas aeruginosa / Anti-Bacterial Agents Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Campina Grande/BR / Federal University of Paraíba/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pseudomonas aeruginosa / Anti-Bacterial Agents Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Campina Grande/BR / Federal University of Paraíba/BR